DEFICIT OF SPECIFIC THYMUS-DEPENDENT LYMPHOCYTES IN TRANSPLANTATION TOLERANCE IN THE RAT

Recovery from adoptively terminated transplantation tolerance was studied by utilizing formerly tolerant rats as donors of lymphocytes in local renal graft-vs.-host reactions (GVHR). The origin of the proliferating lymphocytes in the GVHR was studied by means of sex chromosome markers. A deficit of...

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Autor principal: Elkins, William L.
Formato: Artigo
Idioma:English
Publicado em: The Rockefeller University Press 1973
Assuntos:
Brief Definitive Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2139233/
https://ncbi.nlm.nih.gov/pubmed/4144309
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spelling pubmed-21392332008-04-17 DEFICIT OF SPECIFIC THYMUS-DEPENDENT LYMPHOCYTES IN TRANSPLANTATION TOLERANCE IN THE RAT Elkins, William L. J Exp Med Brief Definitive Reports Recovery from adoptively terminated transplantation tolerance was studied by utilizing formerly tolerant rats as donors of lymphocytes in local renal graft-vs.-host reactions (GVHR). The origin of the proliferating lymphocytes in the GVHR was studied by means of sex chromosome markers. A deficit of specifically reactive lymphocytes, while tolerance was in effect, was revealed by the continuing absence of autochthonous specifically reactive cells after tolerance was abolished in adult thymectomized chimeras. The findings are consistent with Burnet's hypothesis of the cellular basis of tolerance, but apply only to the T lymphocytes of donor origin which normally proliferate in these GVHR. The Rockefeller University Press 1973-03-31 /pmc/articles/PMC2139233/ /pubmed/4144309 Text en Copyright © 1973 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
institution US National Library of Medicine
collection PubMed Central
language English
format Article
topic Brief Definitive Reports
spellingShingle Brief Definitive Reports
Elkins, William L.
DEFICIT OF SPECIFIC THYMUS-DEPENDENT LYMPHOCYTES IN TRANSPLANTATION TOLERANCE IN THE RAT
description Recovery from adoptively terminated transplantation tolerance was studied by utilizing formerly tolerant rats as donors of lymphocytes in local renal graft-vs.-host reactions (GVHR). The origin of the proliferating lymphocytes in the GVHR was studied by means of sex chromosome markers. A deficit of specifically reactive lymphocytes, while tolerance was in effect, was revealed by the continuing absence of autochthonous specifically reactive cells after tolerance was abolished in adult thymectomized chimeras. The findings are consistent with Burnet's hypothesis of the cellular basis of tolerance, but apply only to the T lymphocytes of donor origin which normally proliferate in these GVHR.
author Elkins, William L.
author_facet Elkins, William L.
author_sort Elkins, William L.
title DEFICIT OF SPECIFIC THYMUS-DEPENDENT LYMPHOCYTES IN TRANSPLANTATION TOLERANCE IN THE RAT
title_short DEFICIT OF SPECIFIC THYMUS-DEPENDENT LYMPHOCYTES IN TRANSPLANTATION TOLERANCE IN THE RAT
title_full DEFICIT OF SPECIFIC THYMUS-DEPENDENT LYMPHOCYTES IN TRANSPLANTATION TOLERANCE IN THE RAT
title_fullStr DEFICIT OF SPECIFIC THYMUS-DEPENDENT LYMPHOCYTES IN TRANSPLANTATION TOLERANCE IN THE RAT
title_full_unstemmed DEFICIT OF SPECIFIC THYMUS-DEPENDENT LYMPHOCYTES IN TRANSPLANTATION TOLERANCE IN THE RAT
title_sort deficit of specific thymus-dependent lymphocytes in transplantation tolerance in the rat
publisher The Rockefeller University Press
publisher_facet The Rockefeller University Press
publishDate 1973
url https://ncbi.nlm.nih.gov/pmc/articles/PMC2139233/
https://ncbi.nlm.nih.gov/pubmed/4144309
_version_ 1760515098249527296

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