Llwytho...
THYMUS-DEPENDENT LYMPHOCYTES IN TISSUE SECTIONS OF REJECTING RAT RENAL ALLOGRAFTS
Lewis kidneys were grafted into BN recipients and examined at daily intervals up to 6 days after grafting with immunofluorescent reagents. A horse antiserum specific for T lymphocytes revealed an increasing number of T lymphocytes in the cellular infiltrates of rejecting allografts. These were detec...
Wedi'i Gadw mewn:
| Prif Awduron: | , , , |
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| Fformat: | Erthygl |
| Iaith: | English |
| Cyhoeddwyd: |
The Rockefeller University Press
1973
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2139462/ https://ncbi.nlm.nih.gov/pubmed/4586981 |
| Tagiau: |
Ychwanegu Tag
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| Crynodeb: | Lewis kidneys were grafted into BN recipients and examined at daily intervals up to 6 days after grafting with immunofluorescent reagents. A horse antiserum specific for T lymphocytes revealed an increasing number of T lymphocytes in the cellular infiltrates of rejecting allografts. These were detectable 1 day after grafting, reached a maximum 3 days later, and were relatively diminished at 6 days. In control isografts and nonimmunological inflammations of kidney, a small number of dispersed T lymphocytes was seen. A rabbit antirat thymocyte antiserum, given to allografted BN rats, prolonged survival of the grafts and decreased the cellular infiltrate and the number of T lymphocytes in the infiltrates. We conclude that in graft rejection there is a flow of T lymphocytes into areas of tissue damage and these T lymphocytes are immunologically reactive to graft antigens. |
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