THYMUS-DEPENDENT LYMPHOCYTES IN TISSUE SECTIONS OF REJECTING RAT RENAL ALLOGRAFTS

Lewis kidneys were grafted into BN recipients and examined at daily intervals up to 6 days after grafting with immunofluorescent reagents. A horse antiserum specific for T lymphocytes revealed an increasing number of T lymphocytes in the cellular infiltrates of rejecting allografts. These were detec...

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Main Authors: Balch, C. M., Wilson, C. B., Lee, S., Feldman, J. D.
Formato: Artigo
Idioma:English
Publicado em: The Rockefeller University Press 1973
Assuntos:
Brief Definitive Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2139462/
https://ncbi.nlm.nih.gov/pubmed/4586981
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spelling pubmed-21394622008-04-17 THYMUS-DEPENDENT LYMPHOCYTES IN TISSUE SECTIONS OF REJECTING RAT RENAL ALLOGRAFTS Balch, C. M. Wilson, C. B. Lee, S. Feldman, J. D. J Exp Med Brief Definitive Reports Lewis kidneys were grafted into BN recipients and examined at daily intervals up to 6 days after grafting with immunofluorescent reagents. A horse antiserum specific for T lymphocytes revealed an increasing number of T lymphocytes in the cellular infiltrates of rejecting allografts. These were detectable 1 day after grafting, reached a maximum 3 days later, and were relatively diminished at 6 days. In control isografts and nonimmunological inflammations of kidney, a small number of dispersed T lymphocytes was seen. A rabbit antirat thymocyte antiserum, given to allografted BN rats, prolonged survival of the grafts and decreased the cellular infiltrate and the number of T lymphocytes in the infiltrates. We conclude that in graft rejection there is a flow of T lymphocytes into areas of tissue damage and these T lymphocytes are immunologically reactive to graft antigens. The Rockefeller University Press 1973-11-30 /pmc/articles/PMC2139462/ /pubmed/4586981 Text en Copyright © 1973 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
institution US National Library of Medicine
collection PubMed Central
language English
format Article
topic Brief Definitive Reports
spellingShingle Brief Definitive Reports
Balch, C. M.
Wilson, C. B.
Lee, S.
Feldman, J. D.
THYMUS-DEPENDENT LYMPHOCYTES IN TISSUE SECTIONS OF REJECTING RAT RENAL ALLOGRAFTS
description Lewis kidneys were grafted into BN recipients and examined at daily intervals up to 6 days after grafting with immunofluorescent reagents. A horse antiserum specific for T lymphocytes revealed an increasing number of T lymphocytes in the cellular infiltrates of rejecting allografts. These were detectable 1 day after grafting, reached a maximum 3 days later, and were relatively diminished at 6 days. In control isografts and nonimmunological inflammations of kidney, a small number of dispersed T lymphocytes was seen. A rabbit antirat thymocyte antiserum, given to allografted BN rats, prolonged survival of the grafts and decreased the cellular infiltrate and the number of T lymphocytes in the infiltrates. We conclude that in graft rejection there is a flow of T lymphocytes into areas of tissue damage and these T lymphocytes are immunologically reactive to graft antigens.
author Balch, C. M.
Wilson, C. B.
Lee, S.
Feldman, J. D.
author_facet Balch, C. M.
Wilson, C. B.
Lee, S.
Feldman, J. D.
author_sort Balch, C. M.
title THYMUS-DEPENDENT LYMPHOCYTES IN TISSUE SECTIONS OF REJECTING RAT RENAL ALLOGRAFTS
title_short THYMUS-DEPENDENT LYMPHOCYTES IN TISSUE SECTIONS OF REJECTING RAT RENAL ALLOGRAFTS
title_full THYMUS-DEPENDENT LYMPHOCYTES IN TISSUE SECTIONS OF REJECTING RAT RENAL ALLOGRAFTS
title_fullStr THYMUS-DEPENDENT LYMPHOCYTES IN TISSUE SECTIONS OF REJECTING RAT RENAL ALLOGRAFTS
title_full_unstemmed THYMUS-DEPENDENT LYMPHOCYTES IN TISSUE SECTIONS OF REJECTING RAT RENAL ALLOGRAFTS
title_sort thymus-dependent lymphocytes in tissue sections of rejecting rat renal allografts
publisher The Rockefeller University Press
publisher_facet The Rockefeller University Press
publishDate 1973
url https://ncbi.nlm.nih.gov/pmc/articles/PMC2139462/
https://ncbi.nlm.nih.gov/pubmed/4586981
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