FADD Negatively Regulates Lipopolysaccharide Signaling by Impairing Interleukin-1 Receptor-Associated Kinase 1-MyD88 Interaction

Lipopolysaccharide (LPS) engages Toll-like receptor 4 (TLR4) on various cells to initiate inflammatory and angiogenic pathways. FADD is an adaptor protein involved in death receptor-mediated apoptosis. Here we report a role for FADD in regulation of TLR4 signals in endothelial cells. FADD specifical...

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Hlavní autoři: Zhande, Rachel, Dauphinee, Shauna M., Thomas, James A., Yamamoto, Masahiro, Akira, Shizuo, Karsan, Aly
Médium: Článek
Jazyk:English
Vydáno: American Society for Microbiology (ASM) 2007
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Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2169044/
https://ncbi.nlm.nih.gov/pubmed/17785432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00600-07
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https://ncbi.nlm.nih.gov/pmc/articles/PMC2169044/
https://ncbi.nlm.nih.gov/pubmed/17785432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00600-07

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