Differential var gene expression in the organs of patients dying of falciparum malaria

Sequestration of parasitized erythrocytes in the microcirculation of tissues is thought to be important in the pathogenesis of severe falciparum malaria. A major variant surface antigen, var/Plasmodium falciparum erythrocyte membrane protein 1, expressed on the surface of the infected erythrocyte, m...

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Asıl Yazarlar: Montgomery, Jacqui, Mphande, Fingani A, Berriman, Matthew, Pain, Arnab, Rogerson, Stephen J, Taylor, Terrie E, Molyneux, Malcolm E, Craig, Alister
Materyal Türü: Makale
Dil:English
Baskı/Yayın Bilgisi: Blackwell Publishing Ltd 2007
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Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2170262/
https://ncbi.nlm.nih.gov/pubmed/17617167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2958.2007.05837.x
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spelling pubmed-21702622008-01-03 Differential var gene expression in the organs of patients dying of falciparum malaria Montgomery, Jacqui Mphande, Fingani A Berriman, Matthew Pain, Arnab Rogerson, Stephen J Taylor, Terrie E Molyneux, Malcolm E Craig, Alister Mol Microbiol Research Articles Sequestration of parasitized erythrocytes in the microcirculation of tissues is thought to be important in the pathogenesis of severe falciparum malaria. A major variant surface antigen, var/Plasmodium falciparum erythrocyte membrane protein 1, expressed on the surface of the infected erythrocyte, mediates cytoadherence to vascular endothelium. To address the question of tissue-specific accumulation of variant types, we used the unique resource generated by the clinicopathological study of fatal paediatric malaria in Blantyre, Malawi, to analyse var gene transcription in patients dying with falciparum malaria. Despite up to 102 different var genes being expressed by P. falciparum populations in a single host, only one to two of these genes were expressed at high levels in the brains and hearts of these patients. These major var types differed between organs. However, identical var types were expressed in the brains of multiple patients from a single malaria season. These results provide the first evidence of organ-specific accumulation of P. falciparum variant types and suggest that parasitized erythrocytes can exhibit preferential binding in the body, supporting the hypothesis of cytoadherence-linked pathogenesis. Blackwell Publishing Ltd 2007-08 /pmc/articles/PMC2170262/ /pubmed/17617167 http://dx.doi.org/10.1111/j.1365-2958.2007.05837.x Text en © 2007 Liverpool School of Tropical Medicine; Journal compilation © 2007 Blackwell Publishing Ltd https://creativecommons.org/licenses/by/2.5/ Present address: Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden.Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
institution US National Library of Medicine
collection PubMed Central
language English
format Article
topic Research Articles
spellingShingle Research Articles
Montgomery, Jacqui
Mphande, Fingani A
Berriman, Matthew
Pain, Arnab
Rogerson, Stephen J
Taylor, Terrie E
Molyneux, Malcolm E
Craig, Alister
Differential var gene expression in the organs of patients dying of falciparum malaria
description Sequestration of parasitized erythrocytes in the microcirculation of tissues is thought to be important in the pathogenesis of severe falciparum malaria. A major variant surface antigen, var/Plasmodium falciparum erythrocyte membrane protein 1, expressed on the surface of the infected erythrocyte, mediates cytoadherence to vascular endothelium. To address the question of tissue-specific accumulation of variant types, we used the unique resource generated by the clinicopathological study of fatal paediatric malaria in Blantyre, Malawi, to analyse var gene transcription in patients dying with falciparum malaria. Despite up to 102 different var genes being expressed by P. falciparum populations in a single host, only one to two of these genes were expressed at high levels in the brains and hearts of these patients. These major var types differed between organs. However, identical var types were expressed in the brains of multiple patients from a single malaria season. These results provide the first evidence of organ-specific accumulation of P. falciparum variant types and suggest that parasitized erythrocytes can exhibit preferential binding in the body, supporting the hypothesis of cytoadherence-linked pathogenesis.
author Montgomery, Jacqui
Mphande, Fingani A
Berriman, Matthew
Pain, Arnab
Rogerson, Stephen J
Taylor, Terrie E
Molyneux, Malcolm E
Craig, Alister
author_facet Montgomery, Jacqui
Mphande, Fingani A
Berriman, Matthew
Pain, Arnab
Rogerson, Stephen J
Taylor, Terrie E
Molyneux, Malcolm E
Craig, Alister
author_sort Montgomery, Jacqui
title Differential var gene expression in the organs of patients dying of falciparum malaria
title_short Differential var gene expression in the organs of patients dying of falciparum malaria
title_full Differential var gene expression in the organs of patients dying of falciparum malaria
title_fullStr Differential var gene expression in the organs of patients dying of falciparum malaria
title_full_unstemmed Differential var gene expression in the organs of patients dying of falciparum malaria
title_sort differential var gene expression in the organs of patients dying of falciparum malaria
publisher Blackwell Publishing Ltd
publisher_facet Blackwell Publishing Ltd
publishDate 2007
url https://ncbi.nlm.nih.gov/pmc/articles/PMC2170262/
https://ncbi.nlm.nih.gov/pubmed/17617167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2958.2007.05837.x
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