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Modification of Cysteine Residues In Vitro and In Vivo Affects the Immunogenicity and Antigenicity of Major Histocompatibility Complex Class I–restricted Viral Determinants
In studying the subdominant status of two cysteine-containing influenza virus nuclear protein (NP) determinants (NP(39–47) and NP(218–226)) restricted by H-2K(d), we found that the antigenicity of synthetic peptides was enhanced 10–100-fold by treatment with reducing agents, despite the fact that th...
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| Auteurs principaux: | , , , |
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| Format: | Article |
| Langue: | English |
| Publié: |
The Rockefeller University Press
1999
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2193077/ https://ncbi.nlm.nih.gov/pubmed/10359579 |
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