Phenotypic Characterization of Resistant Val(36) Variants of Hepatitis C Virus NS3-4A Serine Protease

In patients chronically infected with hepatitis C virus (HCV) strains of genotype 1, rapid and dramatic antiviral activity has been observed with telaprevir (VX-950), a highly selective and potent inhibitor of the HCV NS3-4A serine protease. HCV variants with substitutions in the NS3 protease domain...

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Main Authors: Zhou, Yi, Bartels, Doug J., Hanzelka, Brian L., Müh, Ute, Wei, Yunyi, Chu, Hui-May, Tigges, Ann M., Brennan, Debra L., Rao, B. Govinda, Swenson, Lora, Kwong, Ann D., Lin, Chao
Format: Article
Language:English
Published: American Society for Microbiology (ASM) 2008
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2223918/
https://ncbi.nlm.nih.gov/pubmed/17938182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00863-07
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https://ncbi.nlm.nih.gov/pmc/articles/PMC2223918/
https://ncbi.nlm.nih.gov/pubmed/17938182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00863-07

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