Inherited resistance to HIV-1 conferred by an inactivating mutation in CC chemokine receptor 5: studies in populations with contrasting clinical phenotypes, defined racial background, and quantified risk.

BACKGROUND: CC chemokine receptor 5 (CCR5) is a cell entry cofactor for macrophage-tropic isolates of human immunodeficiency virus-1 (HIV-1). Recently, an inactive CCR5 allele (designated here as CCR5-2) was identified that confers resistance to HIV-1 infection in homozygotes and slows the rate of p...

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Hlavní autoři: Zimmerman, P. A., Buckler-White, A., Alkhatib, G., Spalding, T., Kubofcik, J., Combadiere, C., Weissman, D., Cohen, O., Rubbert, A., Lam, G., Vaccarezza, M., Kennedy, P. E., Kumaraswami, V., Giorgi, J. V., Detels, R., Hunter, J., Chopek, M., Berger, E. A., Fauci, A. S., Nutman, T. B., Murphy, P. M.
Médium: Článek
Jazyk:English
Vydáno: The Feinstein Institute for Medical Research 1997
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2230106/
https://ncbi.nlm.nih.gov/pubmed/9132277
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https://ncbi.nlm.nih.gov/pmc/articles/PMC2230106/
https://ncbi.nlm.nih.gov/pubmed/9132277

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