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Cysteine Mutagenesis Reveals Novel Structure–Function Features within the Predicted Third Extracellular Loop of the Type Iia Na(+)/P(i) Cotransporter

The transport function of the rat type IIa Na(+)/P(i) cotransporter is inhibited after binding the cysteine modifying reagent 2-aminoethyl methanethiosulfonate hydrobromide (MTSEA) to a cysteine residue substituted for a serine at position 460 (S460C) in the predicted third extracellular loop. This...

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Auteurs principaux: Lambert, Georg, Forster, Ian C., Stange, Gerti, Köhler, Katja, Biber, Jürg, Murer, Heini
Format: Article
Langue:English
Publié: The Rockefeller University Press 2001
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2232404/
https://ncbi.nlm.nih.gov/pubmed/11382804
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