Tumor Necrosis Factor Receptor 1/c-Jun-NH(2)-Kinase Signaling Promotes Human Neoplasia

The tumor necrosis factor α receptor (TNFR1) activates downstream effectors that include the mitogen-activated protein kinase kinase 7 (MKK7)/c-Jun-NH(2)-kinase (JNK)/activator protein 1 (AP1) cascade. Here, we report that JNK is activated in a majority of spontaneous human squamous cell carcinomas...

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Main Authors: Zhang, Jennifer Y., Adams, Amy E., Ridky, Todd W., Tao, Shiying, Khavari, Paul A.
格式: Artigo
語言:English
出版: 2007
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2239246/
https://ncbi.nlm.nih.gov/pubmed/17440097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-06-4017
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spelling pubmed-22392462008-04-15 Tumor Necrosis Factor Receptor 1/c-Jun-NH(2)-Kinase Signaling Promotes Human Neoplasia Zhang, Jennifer Y. Adams, Amy E. Ridky, Todd W. Tao, Shiying Khavari, Paul A. Cancer Res Article The tumor necrosis factor α receptor (TNFR1) activates downstream effectors that include the mitogen-activated protein kinase kinase 7 (MKK7)/c-Jun-NH(2)-kinase (JNK)/activator protein 1 (AP1) cascade. Here, we report that JNK is activated in a majority of spontaneous human squamous cell carcinomas (SCC). JNK pathway induction bypassed cell cycle restraints induced by oncogenic Ras and cooperated with Ras to convert normal human epidermis into tumors indistinguishable from SCC, confirming its oncogenic potency in human tissue. Inhibiting MKK7, JNK, and AP1 as well as TNFR1 itself using genetic, pharmacologic, or antibody-mediated approaches abolished invasive human epidermal neoplasia in a tumor cell autonomous fashion. The TNFR1/MKK7/JNK/AP1 cascade thus promotes human neoplasia and represents a potential therapeutic target for human epithelial cancers. 2007-04-15 /pmc/articles/PMC2239246/ /pubmed/17440097 http://dx.doi.org/10.1158/0008-5472.CAN-06-4017 Text en
institution US National Library of Medicine
collection PubMed Central
language English
format Article
topic Article
spellingShingle Article
Zhang, Jennifer Y.
Adams, Amy E.
Ridky, Todd W.
Tao, Shiying
Khavari, Paul A.
Tumor Necrosis Factor Receptor 1/c-Jun-NH(2)-Kinase Signaling Promotes Human Neoplasia
description The tumor necrosis factor α receptor (TNFR1) activates downstream effectors that include the mitogen-activated protein kinase kinase 7 (MKK7)/c-Jun-NH(2)-kinase (JNK)/activator protein 1 (AP1) cascade. Here, we report that JNK is activated in a majority of spontaneous human squamous cell carcinomas (SCC). JNK pathway induction bypassed cell cycle restraints induced by oncogenic Ras and cooperated with Ras to convert normal human epidermis into tumors indistinguishable from SCC, confirming its oncogenic potency in human tissue. Inhibiting MKK7, JNK, and AP1 as well as TNFR1 itself using genetic, pharmacologic, or antibody-mediated approaches abolished invasive human epidermal neoplasia in a tumor cell autonomous fashion. The TNFR1/MKK7/JNK/AP1 cascade thus promotes human neoplasia and represents a potential therapeutic target for human epithelial cancers.
author Zhang, Jennifer Y.
Adams, Amy E.
Ridky, Todd W.
Tao, Shiying
Khavari, Paul A.
author_facet Zhang, Jennifer Y.
Adams, Amy E.
Ridky, Todd W.
Tao, Shiying
Khavari, Paul A.
author_sort Zhang, Jennifer Y.
title Tumor Necrosis Factor Receptor 1/c-Jun-NH(2)-Kinase Signaling Promotes Human Neoplasia
title_short Tumor Necrosis Factor Receptor 1/c-Jun-NH(2)-Kinase Signaling Promotes Human Neoplasia
title_full Tumor Necrosis Factor Receptor 1/c-Jun-NH(2)-Kinase Signaling Promotes Human Neoplasia
title_fullStr Tumor Necrosis Factor Receptor 1/c-Jun-NH(2)-Kinase Signaling Promotes Human Neoplasia
title_full_unstemmed Tumor Necrosis Factor Receptor 1/c-Jun-NH(2)-Kinase Signaling Promotes Human Neoplasia
title_sort tumor necrosis factor receptor 1/c-jun-nh(2)-kinase signaling promotes human neoplasia
publishDate 2007
url https://ncbi.nlm.nih.gov/pmc/articles/PMC2239246/
https://ncbi.nlm.nih.gov/pubmed/17440097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-06-4017
_version_ 1760527672241291264

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