Human endogenous retrovirus-FRD envelope protein (syncytin 2) expression in normal and trisomy 21-affected placenta

Human trophoblast expresses two fusogenic retroviral envelope proteins, the widely studied syncytin 1, encoded by HERV-W and the recently characterized syncytin 2 encoded by HERV-FRD. Here we studied syncytin 2 in normal and Trisomy 21-affected placenta associated with abnormal trophoblast different...

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Main Authors: Malassiné, André, Frendo, Jean-Louis, Blaise, Sandra, Handschuh, Karen, Gerbaud, Pascale, Tsatsaris, Vassilis, Heidmann, Thierry, Evain-Brion, Danièle
Formato: Artigo
Idioma:English
Publicado em: BioMed Central 2008
Assuntos:
Short Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2245979/
https://ncbi.nlm.nih.gov/pubmed/18215254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-5-6
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spelling pubmed-22459792008-02-16 Human endogenous retrovirus-FRD envelope protein (syncytin 2) expression in normal and trisomy 21-affected placenta Malassiné, André Frendo, Jean-Louis Blaise, Sandra Handschuh, Karen Gerbaud, Pascale Tsatsaris, Vassilis Heidmann, Thierry Evain-Brion, Danièle Retrovirology Short Report Human trophoblast expresses two fusogenic retroviral envelope proteins, the widely studied syncytin 1, encoded by HERV-W and the recently characterized syncytin 2 encoded by HERV-FRD. Here we studied syncytin 2 in normal and Trisomy 21-affected placenta associated with abnormal trophoblast differentiation. Syncytin 2 immunolocalization was restricted throughout normal pregnancy to some villous cytotrophoblastic cells (CT). During the second trimester of pregnancy, syncytin 2 was immunolocalized in some cuboidal CT in T21 placentas, whereas in normal placentas it was observed in flat CT, extending into their cytoplasmic processes. In vitro, CT isolated from normal placenta fuse and differentiate into syncytiotrophoblast. At the same time, syncytin 2 transcript levels decreased significantly with syncytiotrophoblast formation. In contrast, CT isolated from T21-affected placentas fused and differentiated poorly and no variation in syncytin 2 transcript levels was observed. Syncytin 2 expression illustrates the abnormal trophoblast differentiation observed in placenta of fetal T21-affected pregnancies. BioMed Central 2008-01-23 /pmc/articles/PMC2245979/ /pubmed/18215254 http://dx.doi.org/10.1186/1742-4690-5-6 Text en Copyright © 2008 Malassiné et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
institution US National Library of Medicine
collection PubMed Central
language English
format Article
topic Short Report
spellingShingle Short Report
Malassiné, André
Frendo, Jean-Louis
Blaise, Sandra
Handschuh, Karen
Gerbaud, Pascale
Tsatsaris, Vassilis
Heidmann, Thierry
Evain-Brion, Danièle
Human endogenous retrovirus-FRD envelope protein (syncytin 2) expression in normal and trisomy 21-affected placenta
description Human trophoblast expresses two fusogenic retroviral envelope proteins, the widely studied syncytin 1, encoded by HERV-W and the recently characterized syncytin 2 encoded by HERV-FRD. Here we studied syncytin 2 in normal and Trisomy 21-affected placenta associated with abnormal trophoblast differentiation. Syncytin 2 immunolocalization was restricted throughout normal pregnancy to some villous cytotrophoblastic cells (CT). During the second trimester of pregnancy, syncytin 2 was immunolocalized in some cuboidal CT in T21 placentas, whereas in normal placentas it was observed in flat CT, extending into their cytoplasmic processes. In vitro, CT isolated from normal placenta fuse and differentiate into syncytiotrophoblast. At the same time, syncytin 2 transcript levels decreased significantly with syncytiotrophoblast formation. In contrast, CT isolated from T21-affected placentas fused and differentiated poorly and no variation in syncytin 2 transcript levels was observed. Syncytin 2 expression illustrates the abnormal trophoblast differentiation observed in placenta of fetal T21-affected pregnancies.
author Malassiné, André
Frendo, Jean-Louis
Blaise, Sandra
Handschuh, Karen
Gerbaud, Pascale
Tsatsaris, Vassilis
Heidmann, Thierry
Evain-Brion, Danièle
author_facet Malassiné, André
Frendo, Jean-Louis
Blaise, Sandra
Handschuh, Karen
Gerbaud, Pascale
Tsatsaris, Vassilis
Heidmann, Thierry
Evain-Brion, Danièle
author_sort Malassiné, André
title Human endogenous retrovirus-FRD envelope protein (syncytin 2) expression in normal and trisomy 21-affected placenta
title_short Human endogenous retrovirus-FRD envelope protein (syncytin 2) expression in normal and trisomy 21-affected placenta
title_full Human endogenous retrovirus-FRD envelope protein (syncytin 2) expression in normal and trisomy 21-affected placenta
title_fullStr Human endogenous retrovirus-FRD envelope protein (syncytin 2) expression in normal and trisomy 21-affected placenta
title_full_unstemmed Human endogenous retrovirus-FRD envelope protein (syncytin 2) expression in normal and trisomy 21-affected placenta
title_sort human endogenous retrovirus-frd envelope protein (syncytin 2) expression in normal and trisomy 21-affected placenta
publisher BioMed Central
publisher_facet BioMed Central
publishDate 2008
url https://ncbi.nlm.nih.gov/pmc/articles/PMC2245979/
https://ncbi.nlm.nih.gov/pubmed/18215254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-5-6
_version_ 1760528560214245376

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