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Breast cancer, prostaglandins and patient survival.
Prostaglandins may have both undesirable and desirable effects in malignant disease. Their possible roles in breast cancer were studied by examining the relationships between different variables and the amounts of prostaglandin-like material (PG-LM) extracted from 141 breast carcinomas. Univariate a...
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| Materyal Türü: | Makale |
| Dil: | English |
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Nature Publishing Group
1989
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| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2247010/ https://ncbi.nlm.nih.gov/pubmed/2930691 |
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pubmed-22470102009-09-10 Breast cancer, prostaglandins and patient survival. Bennett, A. Stamford, I. F. Berstock, D. A. Dische, F. Singh, L. A'Hern, R. P. Br J Cancer Research Article Prostaglandins may have both undesirable and desirable effects in malignant disease. Their possible roles in breast cancer were studied by examining the relationships between different variables and the amounts of prostaglandin-like material (PG-LM) extracted from 141 breast carcinomas. Univariate analysis indicates a direct correlation with patient age and menopausal status, with a greater yield from cancers of post- compared with pre-menopausal women. Tumours up to 2 cm diameter yielded more PG-LM than those measuring greater than 2-5 cm. Although there was also a direct correlation with bone metastasis near to the time of surgery, this was because no positive bone scans occurred in patients whose tumours yielded little total PG-LM (less than 16 ng PGE2 equivalents per g tissue). Since tumour PG-LM did not predict later spread to bone, and yields of greater than 16 ng g-1 were similar in the positive and negative bone scan groups, tumour PG-LM appears to be unimportant for skeletal metastasis. There was no obvious relationship of tumour PG-LM to the grade of malignancy, tumour type, amounts of fibrous tissue (and therefore malignant cells), invasion of blood vessels and lymphatics or presence of plasma cells. Multivariate analysis indicates that disease-free survival is longest with an intermediate production of tumour total PG-LM. Of the 82 patients now dead, the cause was attributed to metastatic disease in 69 cases. No relationship of PG-LM to the length of survival was seen with univariate or multivariate analysis. However, when just the post-menopausal patients who died within the first 3 postoperative years were analysed, there was a highly significant inverse correlation between the tumour total PG-LM and the time to death. The reason(s) for these different findings on overall survival compared with just the patients who died are not understood, but the results may indicate that one or more other variables must co-exist with a high tumour PG-LM to hasten death. Nature Publishing Group 1989-02 /pmc/articles/PMC2247010/ /pubmed/2930691 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
| institution |
US National Library of Medicine |
| collection |
PubMed Central |
| language |
English |
| format |
Article |
| topic |
Research Article |
| spellingShingle |
Research Article Bennett, A. Stamford, I. F. Berstock, D. A. Dische, F. Singh, L. A'Hern, R. P. Breast cancer, prostaglandins and patient survival. |
| description |
Prostaglandins may have both undesirable and desirable effects in malignant disease. Their possible roles in breast cancer were studied by examining the relationships between different variables and the amounts of prostaglandin-like material (PG-LM) extracted from 141 breast carcinomas. Univariate analysis indicates a direct correlation with patient age and menopausal status, with a greater yield from cancers of post- compared with pre-menopausal women. Tumours up to 2 cm diameter yielded more PG-LM than those measuring greater than 2-5 cm. Although there was also a direct correlation with bone metastasis near to the time of surgery, this was because no positive bone scans occurred in patients whose tumours yielded little total PG-LM (less than 16 ng PGE2 equivalents per g tissue). Since tumour PG-LM did not predict later spread to bone, and yields of greater than 16 ng g-1 were similar in the positive and negative bone scan groups, tumour PG-LM appears to be unimportant for skeletal metastasis. There was no obvious relationship of tumour PG-LM to the grade of malignancy, tumour type, amounts of fibrous tissue (and therefore malignant cells), invasion of blood vessels and lymphatics or presence of plasma cells. Multivariate analysis indicates that disease-free survival is longest with an intermediate production of tumour total PG-LM. Of the 82 patients now dead, the cause was attributed to metastatic disease in 69 cases. No relationship of PG-LM to the length of survival was seen with univariate or multivariate analysis. However, when just the post-menopausal patients who died within the first 3 postoperative years were analysed, there was a highly significant inverse correlation between the tumour total PG-LM and the time to death. The reason(s) for these different findings on overall survival compared with just the patients who died are not understood, but the results may indicate that one or more other variables must co-exist with a high tumour PG-LM to hasten death. |
| author |
Bennett, A. Stamford, I. F. Berstock, D. A. Dische, F. Singh, L. A'Hern, R. P. |
| author_facet |
Bennett, A. Stamford, I. F. Berstock, D. A. Dische, F. Singh, L. A'Hern, R. P. |
| author_sort |
Bennett, A. |
| title |
Breast cancer, prostaglandins and patient survival. |
| title_short |
Breast cancer, prostaglandins and patient survival. |
| title_full |
Breast cancer, prostaglandins and patient survival. |
| title_fullStr |
Breast cancer, prostaglandins and patient survival. |
| title_full_unstemmed |
Breast cancer, prostaglandins and patient survival. |
| title_sort |
breast cancer, prostaglandins and patient survival. |
| publisher |
Nature Publishing Group |
| publisher_facet |
Nature Publishing Group |
| publishDate |
1989 |
| url |
https://ncbi.nlm.nih.gov/pmc/articles/PMC2247010/ https://ncbi.nlm.nih.gov/pubmed/2930691 |
| _version_ |
1760528691046121472 |