Activation of retinoid X receptors induces apoptosis in HL-60 cell lines.

Retinoids induce myeloblastic leukemia (HL-60) cells to differentiate into granulocytes, which subsequently die by apoptosis. Retinoid action is mediated through at least two classes of nuclear receptors: retinoic acid receptors, which bind both all-trans retinoic acid and 9-cis retinoic acid, and r...

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Prif Awduron: Nagy, L, Thomázy, V A, Shipley, G L, Fésüs, L, Lamph, W, Heyman, R A, Chandraratna, R A, Davies, P J
Fformat: Erthygl
Iaith:en
Cyhoeddwyd: 1995
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC230591/
https://ncbi.nlm.nih.gov/pubmed/7791761
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id pubmed-230591
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spelling pubmed-2305912003-10-28 Activation of retinoid X receptors induces apoptosis in HL-60 cell lines. Nagy, L Thomázy, V A Shipley, G L Fésüs, L Lamph, W Heyman, R A Chandraratna, R A Davies, P J Mol Cell Biol Research Article Retinoids induce myeloblastic leukemia (HL-60) cells to differentiate into granulocytes, which subsequently die by apoptosis. Retinoid action is mediated through at least two classes of nuclear receptors: retinoic acid receptors, which bind both all-trans retinoic acid and 9-cis retinoic acid, and retinoid X receptors, which bind only 9-cis retinoic acid. Using receptor-selective synthetic retinoids and HL-60 cell sublines with different retinoid responsiveness, we have investigated the contribution that each class of receptors makes to the processes of cellular differentiation and death. Our results demonstrate that ligand activation of retinoic acid receptors is sufficient to induce differentiation, whereas ligand activation of retinoid X receptors is essential for the induction of apoptosis in HL-60 cell lines. 1995-07 /pmc/articles/PMC230591/ /pubmed/7791761 Text en
institution US National Library of Medicine
collection PubMed Central
language en
format Article
topic Research Article
spellingShingle Research Article
Nagy, L
Thomázy, V A
Shipley, G L
Fésüs, L
Lamph, W
Heyman, R A
Chandraratna, R A
Davies, P J
Activation of retinoid X receptors induces apoptosis in HL-60 cell lines.
description Retinoids induce myeloblastic leukemia (HL-60) cells to differentiate into granulocytes, which subsequently die by apoptosis. Retinoid action is mediated through at least two classes of nuclear receptors: retinoic acid receptors, which bind both all-trans retinoic acid and 9-cis retinoic acid, and retinoid X receptors, which bind only 9-cis retinoic acid. Using receptor-selective synthetic retinoids and HL-60 cell sublines with different retinoid responsiveness, we have investigated the contribution that each class of receptors makes to the processes of cellular differentiation and death. Our results demonstrate that ligand activation of retinoic acid receptors is sufficient to induce differentiation, whereas ligand activation of retinoid X receptors is essential for the induction of apoptosis in HL-60 cell lines.
author Nagy, L
Thomázy, V A
Shipley, G L
Fésüs, L
Lamph, W
Heyman, R A
Chandraratna, R A
Davies, P J
author_facet Nagy, L
Thomázy, V A
Shipley, G L
Fésüs, L
Lamph, W
Heyman, R A
Chandraratna, R A
Davies, P J
author_sort Nagy, L
title Activation of retinoid X receptors induces apoptosis in HL-60 cell lines.
title_short Activation of retinoid X receptors induces apoptosis in HL-60 cell lines.
title_full Activation of retinoid X receptors induces apoptosis in HL-60 cell lines.
title_fullStr Activation of retinoid X receptors induces apoptosis in HL-60 cell lines.
title_full_unstemmed Activation of retinoid X receptors induces apoptosis in HL-60 cell lines.
title_sort activation of retinoid x receptors induces apoptosis in hl-60 cell lines.
publishDate 1995
url https://ncbi.nlm.nih.gov/pmc/articles/PMC230591/
https://ncbi.nlm.nih.gov/pubmed/7791761
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