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In vitro enzymatic activity of human immunodeficiency virus type 1 reverse transcriptase mutants in the highly conserved YMDD amino acid motif correlates with the infectious potential of the proviral genome.

Reverse transcriptases contain a highly conserved YXDD amino acid motif believed to be important in enzyme function. The second amino acid is not strictly conserved, with a methionine, valine or alanine occupying the second position in reverse transcriptases from various retroviruses and retroelemen...

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Hauptverfasser:	Wakefield, J K, Jablonski, S A, Morrow, C D, Barik, S, Perfumo, S, Amicone, L, Colloca, S, Giorgio, M, Pozzi, L, Tripodi, M, Nagy, P D, Bujarski, J J, Blissard, G W, Wenz, J R, Kool, D A, Matsui, S M, Greenberg, H B, Holmes, I H, Wang, Yei-Shung, Subba-Rao, R. V., Alexander, Martin, Stevenson, R. M. W., Airdrie, D. W., Richardson, K E, Hagler, W M, Hamilton, P B, Goliński, P, Hult, K, Grabarkiewicz-Szczesna, J, Chełkowski, J, Kneblewski, P, Szebiotko, K, Bok, Song H., Seidman, Martin, Wopat, Paula W., Buchanan, R L, Lewis, D F, Toivola, Ansa, Yarrow, David, van den Bosch, Eduard, van Dijken, Johannes P., Scheffers, W. Alexander, McKellar, R. C., Cholette, H., Dingman, D. W., Stahly, Donald P., Calomiris, J J, Armstrong, J L, Seidler, R J, Kenyon, J E, Piexoto, D R, Austin, B, Gillies, D C, Lafon-Lafourcade, S., Geneix, C., Ribéreau-Gayon, P., Thornhill, Patrick J., Cogan, Timothy M., Zhang, J, Temin, H M, Lidstrom, Mary E., Somers, Leslie, Lu, X, Welsh, T M, Peterlin, B M, Larsen, Jens L., Mellergaard, Stig, Williams, Richard T., Crawford, Ronald L., Subbarao, E K, London, W, Murphy, B R, Ogris, E, Rotheneder, H, Mudrak, I, Pichler, A, Wintersberger, E, Dahling, D R, Wright, B A, Hartmanis, Maris G. N., Gatenbeck, Sten, Connor, R I, Mohri, H, Cao, Y, Ho, D D, Rice, S A, Lam, V, Knipe, D M, Johansson, C., Galbally, I. E., Keswick, B H, Gerba, C P, DuPont, H L, Rose, J B, St-Onge, L, Bouchard, L, Bastin, M, Liu, Dickson, Thomson, Karen, Anderson, Ann C., Simkins, S, Alexander, M, Gatei, M H, Good, M F, Daniel, R C, Lavin, M F, Fliermans, C B, Harvey, R S, Guttman-Bass, N, Nasser, A, Naif, H M, Kumar, S, Boyle, D B, Blomquist, Göran K., Ström, Gunnar B., Söderström, Bengt, Ochanda, J O, Syuto, B, Oguma, K, Iida, H, Kubo, S, Young, J A, Bates, P, Varmus, H E, Evans, Patrick J., Wang, Henry Y., Rigby, C E, Kierstead, T D, Tevethia, M J, Smith, Rex L., Schank, S. C., Milam, J. R., Baltensperger, A. A., Armon, R, Kott, Y, Neeman, I, Katoh, I, Yasunaga, T, Yoshinaka, Y, Montazeri, M, Hedrick, H G
Format:	Artikel
Sprache:	English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English
Veröffentlicht:	1992
Schlagworte:	Research Article Errata General Microbial Ecology Applied Environmental and Public Health Microbiology Physiology and Biotechnology Food Microbiology Methods
Online Zugang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC240183/ https://ncbi.nlm.nih.gov/pubmed/1383571 https://ncbi.nlm.nih.gov/pmc/articles/PMC240184/ https://ncbi.nlm.nih.gov/pubmed/1404620 https://ncbi.nlm.nih.gov/pmc/articles/PMC240185/ https://ncbi.nlm.nih.gov/pubmed/1357192 https://ncbi.nlm.nih.gov/pmc/articles/PMC240186/ https://ncbi.nlm.nih.gov/pubmed/1404621 https://ncbi.nlm.nih.gov/pmc/articles/PMC240187/ https://ncbi.nlm.nih.gov/pubmed/1404622 https://ncbi.nlm.nih.gov/pmc/articles/PMC240188/ https://ncbi.nlm.nih.gov/pubmed/1328691 https://ncbi.nlm.nih.gov/pmc/articles/PMC240189/ https://ncbi.nlm.nih.gov/pmc/articles/PMC240194/ https://ncbi.nlm.nih.gov/pubmed/16346555 https://ncbi.nlm.nih.gov/pmc/articles/PMC240195/ https://ncbi.nlm.nih.gov/pubmed/16346556 https://ncbi.nlm.nih.gov/pmc/articles/PMC240196/ https://ncbi.nlm.nih.gov/pubmed/6742839 https://ncbi.nlm.nih.gov/pmc/articles/PMC240197/ https://ncbi.nlm.nih.gov/pubmed/6742840 https://ncbi.nlm.nih.gov/pmc/articles/PMC240198/ https://ncbi.nlm.nih.gov/pubmed/16346557 https://ncbi.nlm.nih.gov/pmc/articles/PMC240199/ https://ncbi.nlm.nih.gov/pubmed/6331311 https://ncbi.nlm.nih.gov/pmc/articles/PMC240200/ https://ncbi.nlm.nih.gov/pubmed/16346558 https://ncbi.nlm.nih.gov/pmc/articles/PMC240201/ https://ncbi.nlm.nih.gov/pubmed/16346559 https://ncbi.nlm.nih.gov/pmc/articles/PMC240202/ https://ncbi.nlm.nih.gov/pubmed/16346560 https://ncbi.nlm.nih.gov/pmc/articles/PMC240203/ https://ncbi.nlm.nih.gov/pubmed/6742841 https://ncbi.nlm.nih.gov/pmc/articles/PMC240204/ https://ncbi.nlm.nih.gov/pubmed/6742842 https://ncbi.nlm.nih.gov/pmc/articles/PMC240205/ https://ncbi.nlm.nih.gov/pubmed/16346561 https://ncbi.nlm.nih.gov/pmc/articles/PMC240208/ https://ncbi.nlm.nih.gov/pubmed/16346562 https://ncbi.nlm.nih.gov/pmc/articles/PMC240211/ https://ncbi.nlm.nih.gov/pubmed/8445707 https://ncbi.nlm.nih.gov/pmc/articles/PMC240212/ https://ncbi.nlm.nih.gov/pubmed/16346563 https://ncbi.nlm.nih.gov/pmc/articles/PMC240213/ https://ncbi.nlm.nih.gov/pubmed/8445708 https://ncbi.nlm.nih.gov/pmc/articles/PMC240214/ https://ncbi.nlm.nih.gov/pubmed/16346564 https://ncbi.nlm.nih.gov/pmc/articles/PMC240215/ https://ncbi.nlm.nih.gov/pubmed/16346565 https://ncbi.nlm.nih.gov/pmc/articles/PMC240216/ https://ncbi.nlm.nih.gov/pubmed/8445709 https://ncbi.nlm.nih.gov/pmc/articles/PMC240217/ https://ncbi.nlm.nih.gov/pubmed/8445710 https://ncbi.nlm.nih.gov/pmc/articles/PMC240218/ https://ncbi.nlm.nih.gov/pubmed/6331312 https://ncbi.nlm.nih.gov/pmc/articles/PMC240219/ https://ncbi.nlm.nih.gov/pubmed/16346566 https://ncbi.nlm.nih.gov/pmc/articles/PMC240220/ https://ncbi.nlm.nih.gov/pubmed/8095306 https://ncbi.nlm.nih.gov/pmc/articles/PMC240221/ https://ncbi.nlm.nih.gov/pubmed/8383210 https://ncbi.nlm.nih.gov/pmc/articles/PMC240222/ https://ncbi.nlm.nih.gov/pubmed/16346567 https://ncbi.nlm.nih.gov/pmc/articles/PMC240223/ https://ncbi.nlm.nih.gov/pubmed/6331313 https://ncbi.nlm.nih.gov/pmc/articles/PMC240224/ https://ncbi.nlm.nih.gov/pubmed/8445711 https://ncbi.nlm.nih.gov/pmc/articles/PMC240225/ https://ncbi.nlm.nih.gov/pubmed/16346568 https://ncbi.nlm.nih.gov/pmc/articles/PMC240226/ https://ncbi.nlm.nih.gov/pubmed/6742843 https://ncbi.nlm.nih.gov/pmc/articles/PMC240227/ https://ncbi.nlm.nih.gov/pubmed/7680386 https://ncbi.nlm.nih.gov/pmc/articles/PMC240228/ https://ncbi.nlm.nih.gov/pubmed/6742844 https://ncbi.nlm.nih.gov/pmc/articles/PMC240229/ https://ncbi.nlm.nih.gov/pubmed/6331314 https://ncbi.nlm.nih.gov/pmc/articles/PMC240230/ https://ncbi.nlm.nih.gov/pubmed/7680387 https://ncbi.nlm.nih.gov/pmc/articles/PMC240231/ https://ncbi.nlm.nih.gov/pubmed/16346569 https://ncbi.nlm.nih.gov/pmc/articles/PMC240232/ https://ncbi.nlm.nih.gov/pubmed/6204594 https://ncbi.nlm.nih.gov/pmc/articles/PMC240233/ https://ncbi.nlm.nih.gov/pubmed/8383211 https://ncbi.nlm.nih.gov/pmc/articles/PMC240234/ https://ncbi.nlm.nih.gov/pubmed/16346570 https://ncbi.nlm.nih.gov/pmc/articles/PMC240235/ https://ncbi.nlm.nih.gov/pubmed/6378094 https://ncbi.nlm.nih.gov/pmc/articles/PMC240236/ https://ncbi.nlm.nih.gov/pubmed/8383212 https://ncbi.nlm.nih.gov/pmc/articles/PMC240237/ https://ncbi.nlm.nih.gov/pubmed/16346571 https://ncbi.nlm.nih.gov/pmc/articles/PMC240238/ https://ncbi.nlm.nih.gov/pubmed/6331315 https://ncbi.nlm.nih.gov/pmc/articles/PMC240239/ https://ncbi.nlm.nih.gov/pubmed/8383213 https://ncbi.nlm.nih.gov/pmc/articles/PMC240240/ https://ncbi.nlm.nih.gov/pubmed/6378095
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In vitro enzymatic activity of human immunodeficiency virus type 1 reverse transcriptase mutants in the highly conserved YMDD amino acid motif correlates with the infectious potential of the proviral genome.

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