Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype

This report details the standardized experimental design and the different data streams that were collected (histopathology, clinical chemistry, hematology and gene expression from the target tissue (liver) and a bio-available tissue (blood)) after treatment with eight known hepatotoxicants (at mult...

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Detalhes bibliográficos
Main Authors: Lobenhofer, Edward K, Auman, J Todd, Blackshear, Pamela E, Boorman, Gary A, Bushel, Pierre R, Cunningham, Michael L, Fostel, Jennifer M, Gerrish, Kevin, Heinloth, Alexandra N, Irwin, Richard D, Malarkey, David E, Merrick, B Alex, Sieber, Stella O, Tucker, Charles J, Ward, Sandra M, Wilson, Ralph E, Hurban, Patrick, Tennant, Raymond W, Paules, Richard S
Formato: Artigo
Idioma:English
Publicado em: BioMed Central 2008
Assuntos:
Method
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2481421/
https://ncbi.nlm.nih.gov/pubmed/18570634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2008-9-6-r100
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Descrição
Resumo:This report details the standardized experimental design and the different data streams that were collected (histopathology, clinical chemistry, hematology and gene expression from the target tissue (liver) and a bio-available tissue (blood)) after treatment with eight known hepatotoxicants (at multiple time points and doses with multiple biological replicates). The results of the study demonstrate the classification of histopathological differences, likely reflecting differences in mechanisms of cell-specific toxicity, using either liver tissue or blood transcriptomic data.

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