Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype

This report details the standardized experimental design and the different data streams that were collected (histopathology, clinical chemistry, hematology and gene expression from the target tissue (liver) and a bio-available tissue (blood)) after treatment with eight known hepatotoxicants (at mult...

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Main Authors: Lobenhofer, Edward K, Auman, J Todd, Blackshear, Pamela E, Boorman, Gary A, Bushel, Pierre R, Cunningham, Michael L, Fostel, Jennifer M, Gerrish, Kevin, Heinloth, Alexandra N, Irwin, Richard D, Malarkey, David E, Merrick, B Alex, Sieber, Stella O, Tucker, Charles J, Ward, Sandra M, Wilson, Ralph E, Hurban, Patrick, Tennant, Raymond W, Paules, Richard S
Formato: Artigo
Idioma:English
Publicado em: BioMed Central 2008
Assuntos:
Method
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2481421/
https://ncbi.nlm.nih.gov/pubmed/18570634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2008-9-6-r100
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spelling pubmed-24814212008-07-24 Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype Lobenhofer, Edward K Auman, J Todd Blackshear, Pamela E Boorman, Gary A Bushel, Pierre R Cunningham, Michael L Fostel, Jennifer M Gerrish, Kevin Heinloth, Alexandra N Irwin, Richard D Malarkey, David E Merrick, B Alex Sieber, Stella O Tucker, Charles J Ward, Sandra M Wilson, Ralph E Hurban, Patrick Tennant, Raymond W Paules, Richard S Genome Biol Method This report details the standardized experimental design and the different data streams that were collected (histopathology, clinical chemistry, hematology and gene expression from the target tissue (liver) and a bio-available tissue (blood)) after treatment with eight known hepatotoxicants (at multiple time points and doses with multiple biological replicates). The results of the study demonstrate the classification of histopathological differences, likely reflecting differences in mechanisms of cell-specific toxicity, using either liver tissue or blood transcriptomic data. BioMed Central 2008 2008-06-20 /pmc/articles/PMC2481421/ /pubmed/18570634 http://dx.doi.org/10.1186/gb-2008-9-6-r100 Text en Copyright © 2008 Lobenhofer et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
institution US National Library of Medicine
collection PubMed Central
language English
format Article
topic Method
spellingShingle Method
Lobenhofer, Edward K
Auman, J Todd
Blackshear, Pamela E
Boorman, Gary A
Bushel, Pierre R
Cunningham, Michael L
Fostel, Jennifer M
Gerrish, Kevin
Heinloth, Alexandra N
Irwin, Richard D
Malarkey, David E
Merrick, B Alex
Sieber, Stella O
Tucker, Charles J
Ward, Sandra M
Wilson, Ralph E
Hurban, Patrick
Tennant, Raymond W
Paules, Richard S
Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype
description This report details the standardized experimental design and the different data streams that were collected (histopathology, clinical chemistry, hematology and gene expression from the target tissue (liver) and a bio-available tissue (blood)) after treatment with eight known hepatotoxicants (at multiple time points and doses with multiple biological replicates). The results of the study demonstrate the classification of histopathological differences, likely reflecting differences in mechanisms of cell-specific toxicity, using either liver tissue or blood transcriptomic data.
author Lobenhofer, Edward K
Auman, J Todd
Blackshear, Pamela E
Boorman, Gary A
Bushel, Pierre R
Cunningham, Michael L
Fostel, Jennifer M
Gerrish, Kevin
Heinloth, Alexandra N
Irwin, Richard D
Malarkey, David E
Merrick, B Alex
Sieber, Stella O
Tucker, Charles J
Ward, Sandra M
Wilson, Ralph E
Hurban, Patrick
Tennant, Raymond W
Paules, Richard S
author_facet Lobenhofer, Edward K
Auman, J Todd
Blackshear, Pamela E
Boorman, Gary A
Bushel, Pierre R
Cunningham, Michael L
Fostel, Jennifer M
Gerrish, Kevin
Heinloth, Alexandra N
Irwin, Richard D
Malarkey, David E
Merrick, B Alex
Sieber, Stella O
Tucker, Charles J
Ward, Sandra M
Wilson, Ralph E
Hurban, Patrick
Tennant, Raymond W
Paules, Richard S
author_sort Lobenhofer, Edward K
title Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype
title_short Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype
title_full Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype
title_fullStr Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype
title_full_unstemmed Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype
title_sort gene expression response in target organ and whole blood varies as a function of target organ injury phenotype
publisher BioMed Central
publisher_facet BioMed Central
publishDate 2008
url https://ncbi.nlm.nih.gov/pmc/articles/PMC2481421/
https://ncbi.nlm.nih.gov/pubmed/18570634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2008-9-6-r100
_version_ 1760726495546834944

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