Prep1 Deficiency Induces Protection from Diabetes and Increased Insulin Sensitivity through a p160-Mediated Mechanism

We have examined glucose homeostasis in mice hypomorphic for the homeotic transcription factor gene Prep1. Prep1-hypomorphic (Prep1(i)(/)(i)) mice exhibit an absolute reduction in circulating insulin levels but normal glucose tolerance. In addition, these mice exhibit protection from streptozotocin-...

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Hlavní autoři: Oriente, Francesco, Fernandez Diaz, Luis Cesar, Miele, Claudia, Iovino, Salvatore, Mori, Silvia, Diaz, Victor Manuel, Troncone, Giancarlo, Cassese, Angela, Formisano, Pietro, Blasi, Francesco, Beguinot, Francesco
Médium: Článek
Jazyk:English
Vydáno: American Society for Microbiology (ASM) 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2546928/
https://ncbi.nlm.nih.gov/pubmed/18644868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00117-08
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https://ncbi.nlm.nih.gov/pmc/articles/PMC2546928/
https://ncbi.nlm.nih.gov/pubmed/18644868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00117-08

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