An Alphavirus Replicon-Based Human Metapneumovirus Vaccine Is Immunogenic and Protective in Mice and Cotton Rats

Human metapneumovirus (hMPV) is a recently discovered paramyxovirus that causes upper and lower respiratory tract infections in infants, the elderly, and immunocompromised individuals worldwide. Here, we developed Venezuelan equine encephalitis virus replicon particles (VRPs) encoding hMPV fusion (F...

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Hlavní autoři: Mok, Hoyin, Tollefson, Sharon J., Podsiad, Amy B., Shepherd, Bryan E., Polosukhin, Vasiliy V., Johnston, Robert E., Williams, John V., Crowe, James E.
Médium: Článek
Jazyk:English
Vydáno: American Society for Microbiology (ASM) 2008
Témata:
Vaccines and Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2573258/
https://ncbi.nlm.nih.gov/pubmed/18786987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01688-08
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https://ncbi.nlm.nih.gov/pmc/articles/PMC2573258/
https://ncbi.nlm.nih.gov/pubmed/18786987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01688-08

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