Both cIAP1 and cIAP2 regulate TNFα-mediated NF-κB activation

The cellular inhibitor of apoptosis 1 and 2 (cIAP1 and cIAP2) proteins have been implicated in the activation of NF-κB by TNFα; however, genetic deletion of either cIAP1 or 2 did not support a physiologically relevant role, perhaps because of functional redundancy. To address this, we used combined...

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Main Authors: Mahoney, D. J., Cheung, H. H., Mrad, R. Lejmi, Plenchette, S., Simard, C., Enwere, E., Arora, V., Mak, T. W., Lacasse, E. C., Waring, J., Korneluk, R. G.
Format: Article
Language:English
Published: National Academy of Sciences 2008
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575330/
https://ncbi.nlm.nih.gov/pubmed/18697935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711122105
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https://ncbi.nlm.nih.gov/pmc/articles/PMC2575330/
https://ncbi.nlm.nih.gov/pubmed/18697935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711122105

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