G9a and HP1 Couple Histone and DNA Methylation to TNFα Transcription Silencing during Endotoxin Tolerance

TNFα gene expression is silenced in the endotoxin tolerant phenotype that develops in blood leukocytes after the initial activation phase of severe systemic inflammation or sepsis. The silencing phase can be mimicked in vitro by LPS stimulation. We reported that the TNFα transcription is disrupted i...

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Autori principali: Gazzar, Mohamed El, Yoza, Barbara K., Chen, Xiaoping, Hu, Jean, Hawkins, Gregory A., McCall, Charles E.
Natura: Articolo
Lingua:English
Pubblicazione: American Society for Biochemistry and Molecular Biology 2008
Soggetti:
Transcription, Chromatin, and Epigenetics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2583293/
https://ncbi.nlm.nih.gov/pubmed/18809684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803446200
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Accesso online

https://ncbi.nlm.nih.gov/pmc/articles/PMC2583293/
https://ncbi.nlm.nih.gov/pubmed/18809684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803446200

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