Intraocular Pressure, Central Corneal Thickness, and Prevalence of Open-Angle Glaucoma: The Los Angeles Latino Eye Study

PURPOSE: To examine the relationship between the prevalence of open-angle glaucoma (OAG) and intraocular pressure (IOP) and the impact of central corneal thickness (CCT) on this relationship. DESIGN: Population based cross-sectional study. METHODS: The study cohort consisted of 5970 participants fro...

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Autors principals: Francis, Brian A., Varma, Rohit, Chopra, Vikas, Lai, Mei-Ying, Shtir, Corina, Azen, Stanley P.
Format: Article
Idioma:English
Publicat: 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2583935/
https://ncbi.nlm.nih.gov/pubmed/18672218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajo.2008.05.048
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spelling pubmed-25839352009-11-01 Intraocular Pressure, Central Corneal Thickness, and Prevalence of Open-Angle Glaucoma: The Los Angeles Latino Eye Study Francis, Brian A. Varma, Rohit Chopra, Vikas Lai, Mei-Ying Shtir, Corina Azen, Stanley P. Am J Ophthalmol Article PURPOSE: To examine the relationship between the prevalence of open-angle glaucoma (OAG) and intraocular pressure (IOP) and the impact of central corneal thickness (CCT) on this relationship. DESIGN: Population based cross-sectional study. METHODS: The study cohort consisted of 5970 participants from the Los Angeles Latino Eye Study (LALES) with no history of glaucoma treatment and with complete ophthalmic examination data. The relationship between the prevalence of OAG and IOP was contrasted across persons with CCT designated as thin, normal or thick. RESULTS: Prevalence of OAG was exponentially related to IOP. When stratified by CCT, persons with thin CCT had a significantly higher prevalence of OAG than did those with normal or thick CCT’s at all levels of IOP. Adjusting each IOP individually for CCT did not impact significantly the relationship between the prevalence of OAG and IOP. CONCLUSIONS: These findings suggest that adjusting for the impact of CCT on IOP by correction algorithms is not necessary in a population analysis of glaucoma prevalence; CCT and other associated corneal properties, however, are important independent risk factors for the prevalence of OAG. 2008-07-30 2008-11 /pmc/articles/PMC2583935/ /pubmed/18672218 http://dx.doi.org/10.1016/j.ajo.2008.05.048 Text en
institution US National Library of Medicine
collection PubMed Central
language English
format Article
topic Article
spellingShingle Article
Francis, Brian A.
Varma, Rohit
Chopra, Vikas
Lai, Mei-Ying
Shtir, Corina
Azen, Stanley P.
Intraocular Pressure, Central Corneal Thickness, and Prevalence of Open-Angle Glaucoma: The Los Angeles Latino Eye Study
description PURPOSE: To examine the relationship between the prevalence of open-angle glaucoma (OAG) and intraocular pressure (IOP) and the impact of central corneal thickness (CCT) on this relationship. DESIGN: Population based cross-sectional study. METHODS: The study cohort consisted of 5970 participants from the Los Angeles Latino Eye Study (LALES) with no history of glaucoma treatment and with complete ophthalmic examination data. The relationship between the prevalence of OAG and IOP was contrasted across persons with CCT designated as thin, normal or thick. RESULTS: Prevalence of OAG was exponentially related to IOP. When stratified by CCT, persons with thin CCT had a significantly higher prevalence of OAG than did those with normal or thick CCT’s at all levels of IOP. Adjusting each IOP individually for CCT did not impact significantly the relationship between the prevalence of OAG and IOP. CONCLUSIONS: These findings suggest that adjusting for the impact of CCT on IOP by correction algorithms is not necessary in a population analysis of glaucoma prevalence; CCT and other associated corneal properties, however, are important independent risk factors for the prevalence of OAG.
author Francis, Brian A.
Varma, Rohit
Chopra, Vikas
Lai, Mei-Ying
Shtir, Corina
Azen, Stanley P.
author_facet Francis, Brian A.
Varma, Rohit
Chopra, Vikas
Lai, Mei-Ying
Shtir, Corina
Azen, Stanley P.
author_sort Francis, Brian A.
title Intraocular Pressure, Central Corneal Thickness, and Prevalence of Open-Angle Glaucoma: The Los Angeles Latino Eye Study
title_short Intraocular Pressure, Central Corneal Thickness, and Prevalence of Open-Angle Glaucoma: The Los Angeles Latino Eye Study
title_full Intraocular Pressure, Central Corneal Thickness, and Prevalence of Open-Angle Glaucoma: The Los Angeles Latino Eye Study
title_fullStr Intraocular Pressure, Central Corneal Thickness, and Prevalence of Open-Angle Glaucoma: The Los Angeles Latino Eye Study
title_full_unstemmed Intraocular Pressure, Central Corneal Thickness, and Prevalence of Open-Angle Glaucoma: The Los Angeles Latino Eye Study
title_sort intraocular pressure, central corneal thickness, and prevalence of open-angle glaucoma: the los angeles latino eye study
publishDate 2008
url https://ncbi.nlm.nih.gov/pmc/articles/PMC2583935/
https://ncbi.nlm.nih.gov/pubmed/18672218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajo.2008.05.048
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