Structural Plasticity Controlled by Calcium Based Correlation Detection

Hebbian learning in cortical networks during development and adulthood relies on the presence of a mechanism to detect correlation between the presynaptic and the postsynaptic spiking activity. Recently, the calcium concentration in spines was experimentally shown to be a correlation sensitive signa...

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Những tác giả chính: Helias, Moritz, Rotter, Stefan, Gewaltig, Marc-Oliver, Diesmann, Markus
Định dạng: Bài viết
Ngôn ngữ:English
Được phát hành: Frontiers Research Foundation 2008
Những chủ đề:
Neuroscience
Truy cập trực tuyến:https://ncbi.nlm.nih.gov/pmc/articles/PMC2614616/
https://ncbi.nlm.nih.gov/pubmed/19129936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/neuro.10.007.2008
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id pubmed-2614616
record_format dspace
spelling pubmed-26146162009-01-07 Structural Plasticity Controlled by Calcium Based Correlation Detection Helias, Moritz Rotter, Stefan Gewaltig, Marc-Oliver Diesmann, Markus Front Comput Neurosci Neuroscience Hebbian learning in cortical networks during development and adulthood relies on the presence of a mechanism to detect correlation between the presynaptic and the postsynaptic spiking activity. Recently, the calcium concentration in spines was experimentally shown to be a correlation sensitive signal with the necessary properties: it is confined to the spine volume, it depends on the relative timing of pre- and postsynaptic action potentials, and it is independent of the spine's location along the dendrite. NMDA receptors are a candidate mediator for the correlation dependent calcium signal. Here, we present a quantitative model of correlation detection in synapses based on the calcium influx through NMDA receptors under realistic conditions of irregular pre- and postsynaptic spiking activity with pairwise correlation. Our analytical framework captures the interaction of the learning rule and the correlation dynamics of the neurons. We find that a simple thresholding mechanism can act as a sensitive and reliable correlation detector at physiological firing rates. Furthermore, the mechanism is sensitive to correlation among afferent synapses by cooperation and competition. In our model this mechanism controls synapse formation and elimination. We explain how synapse elimination leads to firing rate homeostasis and show that the connectivity structure is shaped by the correlations between neighboring inputs. Frontiers Research Foundation 2008-12-24 /pmc/articles/PMC2614616/ /pubmed/19129936 http://dx.doi.org/10.3389/neuro.10.007.2008 Text en Copyright © 2008 Helias, Rotter, Gewaltig and Diesmann. http://www.frontiersin.org/licenseagreement This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.
institution US National Library of Medicine
collection PubMed Central
language English
format Article
topic Neuroscience
spellingShingle Neuroscience
Helias, Moritz
Rotter, Stefan
Gewaltig, Marc-Oliver
Diesmann, Markus
Structural Plasticity Controlled by Calcium Based Correlation Detection
description Hebbian learning in cortical networks during development and adulthood relies on the presence of a mechanism to detect correlation between the presynaptic and the postsynaptic spiking activity. Recently, the calcium concentration in spines was experimentally shown to be a correlation sensitive signal with the necessary properties: it is confined to the spine volume, it depends on the relative timing of pre- and postsynaptic action potentials, and it is independent of the spine's location along the dendrite. NMDA receptors are a candidate mediator for the correlation dependent calcium signal. Here, we present a quantitative model of correlation detection in synapses based on the calcium influx through NMDA receptors under realistic conditions of irregular pre- and postsynaptic spiking activity with pairwise correlation. Our analytical framework captures the interaction of the learning rule and the correlation dynamics of the neurons. We find that a simple thresholding mechanism can act as a sensitive and reliable correlation detector at physiological firing rates. Furthermore, the mechanism is sensitive to correlation among afferent synapses by cooperation and competition. In our model this mechanism controls synapse formation and elimination. We explain how synapse elimination leads to firing rate homeostasis and show that the connectivity structure is shaped by the correlations between neighboring inputs.
author Helias, Moritz
Rotter, Stefan
Gewaltig, Marc-Oliver
Diesmann, Markus
author_facet Helias, Moritz
Rotter, Stefan
Gewaltig, Marc-Oliver
Diesmann, Markus
author_sort Helias, Moritz
title Structural Plasticity Controlled by Calcium Based Correlation Detection
title_short Structural Plasticity Controlled by Calcium Based Correlation Detection
title_full Structural Plasticity Controlled by Calcium Based Correlation Detection
title_fullStr Structural Plasticity Controlled by Calcium Based Correlation Detection
title_full_unstemmed Structural Plasticity Controlled by Calcium Based Correlation Detection
title_sort structural plasticity controlled by calcium based correlation detection
publisher Frontiers Research Foundation
publisher_facet Frontiers Research Foundation
publishDate 2008
url https://ncbi.nlm.nih.gov/pmc/articles/PMC2614616/
https://ncbi.nlm.nih.gov/pubmed/19129936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/neuro.10.007.2008
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