Serological specificity of phenolic glycolipid I from Mycobacterium leprae and use in serodiagnosis of leprosy.

The serological activities of the specific phenolic glycolipid I from Mycobacterium leprae, its dissected parts, and related glycolipids from other mycobacteria were examined by enzyme-linked immunosorbent assay against hyperimmune anti-M. leprae rabbit antiserum and sera from patients with leprosy...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Cho, S N, Yanagihara, D L, Hunter, S W, Gelber, R H, Brennan, P J
Fformat: Erthygl
Iaith:en
Cyhoeddwyd: 1983
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC264610/
https://ncbi.nlm.nih.gov/pubmed/6193065
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!
id pubmed-264610
record_format dspace
spelling pubmed-2646102004-03-04 Serological specificity of phenolic glycolipid I from Mycobacterium leprae and use in serodiagnosis of leprosy. Cho, S N Yanagihara, D L Hunter, S W Gelber, R H Brennan, P J Infect Immun Research Article The serological activities of the specific phenolic glycolipid I from Mycobacterium leprae, its dissected parts, and related glycolipids from other mycobacteria were examined by enzyme-linked immunosorbent assay against hyperimmune anti-M. leprae rabbit antiserum and sera from patients with leprosy and other mycobacterial diseases. High anti-phenolic glycolipid I immunoglobulin M antibodies were found in 23 of 24 (96%) of lepromatous leprosy patients on short term chemotherapy and in 8 of 13 tuberculoid leprosy patients (62%). Sera from patients with tuberculosis or atypical mycobacterial infections were devoid of anti-phenolic glycolipid I activity. The structurally related phenolic glycolipids from Mycobacterium kansasii and Mycobacterium bovis and the aglycone segments of the M. leprae product showed no significant activity. Thus, the trisaccharide determinant of phenolic glycolipid I is specific in its structure, serological activity, and, to a lesser extent, the antibody class it evokes. 1983-09 /pmc/articles/PMC264610/ /pubmed/6193065 Text en
institution US National Library of Medicine
collection PubMed Central
language en
format Article
topic Research Article
spellingShingle Research Article
Cho, S N
Yanagihara, D L
Hunter, S W
Gelber, R H
Brennan, P J
Serological specificity of phenolic glycolipid I from Mycobacterium leprae and use in serodiagnosis of leprosy.
description The serological activities of the specific phenolic glycolipid I from Mycobacterium leprae, its dissected parts, and related glycolipids from other mycobacteria were examined by enzyme-linked immunosorbent assay against hyperimmune anti-M. leprae rabbit antiserum and sera from patients with leprosy and other mycobacterial diseases. High anti-phenolic glycolipid I immunoglobulin M antibodies were found in 23 of 24 (96%) of lepromatous leprosy patients on short term chemotherapy and in 8 of 13 tuberculoid leprosy patients (62%). Sera from patients with tuberculosis or atypical mycobacterial infections were devoid of anti-phenolic glycolipid I activity. The structurally related phenolic glycolipids from Mycobacterium kansasii and Mycobacterium bovis and the aglycone segments of the M. leprae product showed no significant activity. Thus, the trisaccharide determinant of phenolic glycolipid I is specific in its structure, serological activity, and, to a lesser extent, the antibody class it evokes.
author Cho, S N
Yanagihara, D L
Hunter, S W
Gelber, R H
Brennan, P J
author_facet Cho, S N
Yanagihara, D L
Hunter, S W
Gelber, R H
Brennan, P J
author_sort Cho, S N
title Serological specificity of phenolic glycolipid I from Mycobacterium leprae and use in serodiagnosis of leprosy.
title_short Serological specificity of phenolic glycolipid I from Mycobacterium leprae and use in serodiagnosis of leprosy.
title_full Serological specificity of phenolic glycolipid I from Mycobacterium leprae and use in serodiagnosis of leprosy.
title_fullStr Serological specificity of phenolic glycolipid I from Mycobacterium leprae and use in serodiagnosis of leprosy.
title_full_unstemmed Serological specificity of phenolic glycolipid I from Mycobacterium leprae and use in serodiagnosis of leprosy.
title_sort serological specificity of phenolic glycolipid i from mycobacterium leprae and use in serodiagnosis of leprosy.
publishDate 1983
url https://ncbi.nlm.nih.gov/pmc/articles/PMC264610/
https://ncbi.nlm.nih.gov/pubmed/6193065
_version_ 1759074755584983040