Inflammation and mitochondrial fatty acid β-oxidation link obesity to early tumor promotion

Obesity is associated with increased risk for developing pancreatic cancer, and it is suggested that insulin resistance provides the missing link. Here we demonstrate that under the context of genetic susceptibility, a high fat diet (HFD) predisposes mice with oncogenic K-ras activation to accelerat...

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Main Authors: Khasawneh, J., Schulz, M. D., Walch, A., Rozman, J., de Angelis, M. Hrabe, Klingenspor, M., Buck, A., Schwaiger, M., Saur, D., Schmid, R. M., Klöppel, G., Sipos, B., Greten, F. R., Arkan, M. C.
Formato: Artigo
Idioma:English
Publicado: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2651311/
https://ncbi.nlm.nih.gov/pubmed/19208810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802864106
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https://ncbi.nlm.nih.gov/pmc/articles/PMC2651311/
https://ncbi.nlm.nih.gov/pubmed/19208810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802864106

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