Melan-A/MART-1(51–73) represents an immunogenic HLA-DR4-restricted epitope recognized by melanoma-reactive CD4(+) T cells

The human Melan-A/MART-1 gene encodes an HLA-A2-restricted peptide epitope recognized by melanoma-reactive CD8(+) cytotoxic T lymphocytes. Here we report that this gene also encodes at least one HLA-DR4-presented peptide recognized by CD4(+) T cells. The Melan-A/MART-1(51–73) peptide was able to ind...

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Main Authors: Zarour, Hassane M., Kirkwood, John M., Kierstead, Lisa Salvucci, Herr, Wolfgang, Brusic, Vladimir, Slingluff, Craig L., Sidney, John, Sette, Alessandro, Storkus, Walter J.
Format: Artigo
Sprog:en
Udgivet: The National Academy of Sciences 2000
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC26675/
https://ncbi.nlm.nih.gov/pubmed/10618430
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Internet

https://ncbi.nlm.nih.gov/pmc/articles/PMC26675/
https://ncbi.nlm.nih.gov/pubmed/10618430

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