MEK1 Binds Directly to βArrestin1, Influencing Both Its Phosphorylation by ERK and the Timing of Its Isoprenaline-stimulated Internalization

βArrestin is a multifunctional signal scaffold protein. Using SPOT immobilized peptide arrays, coupled with scanning alanine substitution and mutagenesis, we show that the MAPK kinase, MEK1, interacts directly with βarrestin1. Asp(26) and Asp(29) in the N-terminal domain of βarrestin1 are critical f...

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Detaylı Bibliyografya
Asıl Yazarlar: Meng, Dong, Lynch, Martin J., Huston, Elaine, Beyermann, Michael, Eichhorst, Jenny, Adams, David R., Klussmann, Enno, Houslay, Miles D., Baillie, George S.
Materyal Türü: Makale
Dil:English
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2009
Konular:
Mechanisms of Signal Transduction
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670148/
https://ncbi.nlm.nih.gov/pubmed/19153083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806395200
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Internet

https://ncbi.nlm.nih.gov/pmc/articles/PMC2670148/
https://ncbi.nlm.nih.gov/pubmed/19153083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806395200

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