RAP80 Targets BRCA1 to Specific Ubiquitin Structures at DNA Damage Sites

Mutations affecting the BRCT domains of the breast cancer–associated tumor suppressor BRCA1 disrupt the recruitment of this protein to DNA double-strand breaks (DSBs). The molecular structures at DSBs recognized by BRCA1 are presently unknown. We report the interaction of the BRCA1 BRCT domain with...

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Détails bibliographiques
Auteurs principaux: Sobhian, Bijan, Shao, Genze, Lilli, Dana R., Culhane, Aedín C., Moreau, Lisa A., Xia, Bing, Livingston, David M., Greenberg, Roger A.
Format: Article
Langue:English
Publié: 2007
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2706583/
https://ncbi.nlm.nih.gov/pubmed/17525341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1139516
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Internet

https://ncbi.nlm.nih.gov/pmc/articles/PMC2706583/
https://ncbi.nlm.nih.gov/pubmed/17525341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1139516

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