Programmed loss of millions of base pairs from a vertebrate genome

In general, the strict preservation of broad-scale structure is thought to be critical for maintaining the precisely tuned functionality of vertebrate genomes, although nearly all vertebrate species undergo a small number of programmed local rearrangements during development (e.g., remodeling of ada...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Smith, Jeramiah J., Antonacci, Francesca, Eichler, Evan E., Amemiya, Chris T.
Formato: Artigo
Idioma:English
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708698/
https://ncbi.nlm.nih.gov/pubmed/19561299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0902358106
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
id pubmed-2708698
record_format dspace
spelling pubmed-27086982010-01-07 Programmed loss of millions of base pairs from a vertebrate genome Smith, Jeramiah J. Antonacci, Francesca Eichler, Evan E. Amemiya, Chris T. Proc Natl Acad Sci U S A Biological Sciences In general, the strict preservation of broad-scale structure is thought to be critical for maintaining the precisely tuned functionality of vertebrate genomes, although nearly all vertebrate species undergo a small number of programmed local rearrangements during development (e.g., remodeling of adaptive immune receptor loci). However, a limited number of metazoan species undergo much more extensive reorganizations as a normal feature of their development. Here, we show that the sea lamprey (Petromyzon marinus), a jawless vertebrate, undergoes a dramatic remodeling of its genome, resulting in the elimination of hundreds of millions of base pairs (and at least one transcribed locus) from many somatic cell lineages during embryonic development. These studies reveal the highly dynamic nature of the lamprey genome and provide the first example of broad-scale programmed rearrangement of a definitively vertebrate genome. Understanding the mechanisms by which this vertebrate species regulates such extensive remodeling of its genome will provide invaluable insight into factors that can promote stability and change in vertebrate genomes. National Academy of Sciences 2009-07-07 2009-06-26 /pmc/articles/PMC2708698/ /pubmed/19561299 http://dx.doi.org/10.1073/pnas.0902358106 Text en
institution US National Library of Medicine
collection PubMed Central
language English
format Article
topic Biological Sciences
spellingShingle Biological Sciences
Smith, Jeramiah J.
Antonacci, Francesca
Eichler, Evan E.
Amemiya, Chris T.
Programmed loss of millions of base pairs from a vertebrate genome
description In general, the strict preservation of broad-scale structure is thought to be critical for maintaining the precisely tuned functionality of vertebrate genomes, although nearly all vertebrate species undergo a small number of programmed local rearrangements during development (e.g., remodeling of adaptive immune receptor loci). However, a limited number of metazoan species undergo much more extensive reorganizations as a normal feature of their development. Here, we show that the sea lamprey (Petromyzon marinus), a jawless vertebrate, undergoes a dramatic remodeling of its genome, resulting in the elimination of hundreds of millions of base pairs (and at least one transcribed locus) from many somatic cell lineages during embryonic development. These studies reveal the highly dynamic nature of the lamprey genome and provide the first example of broad-scale programmed rearrangement of a definitively vertebrate genome. Understanding the mechanisms by which this vertebrate species regulates such extensive remodeling of its genome will provide invaluable insight into factors that can promote stability and change in vertebrate genomes.
author Smith, Jeramiah J.
Antonacci, Francesca
Eichler, Evan E.
Amemiya, Chris T.
author_facet Smith, Jeramiah J.
Antonacci, Francesca
Eichler, Evan E.
Amemiya, Chris T.
author_sort Smith, Jeramiah J.
title Programmed loss of millions of base pairs from a vertebrate genome
title_short Programmed loss of millions of base pairs from a vertebrate genome
title_full Programmed loss of millions of base pairs from a vertebrate genome
title_fullStr Programmed loss of millions of base pairs from a vertebrate genome
title_full_unstemmed Programmed loss of millions of base pairs from a vertebrate genome
title_sort programmed loss of millions of base pairs from a vertebrate genome
publisher National Academy of Sciences
publisher_facet National Academy of Sciences
publishDate 2009
url https://ncbi.nlm.nih.gov/pmc/articles/PMC2708698/
https://ncbi.nlm.nih.gov/pubmed/19561299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0902358106
_version_ 1760756018247106560