Effects of FK506 on Ca(2+) Release Channels (Review)

Tacrolimus (FK506), which was isolated from the fermentation broth of Streptomyces tsukubaensis No. 9993, has an immunosuppressive effect. In T-lymphocytes, FK506 binds to the intracellular receptor, a 12-kDa FK506-binding protein (FKBP12). The FK506-FKBP12 complex binds to the phosphatase calcineur...

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Bibliographic Details

Main Author:	Ozawa, Terutaka
Format:	Article
Language:	English
Published:	Libertas Academica 2008
Subjects:	Perspective
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2746578/ https://ncbi.nlm.nih.gov/pubmed/19787097
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