Disruption of the CRF(2) Receptor Pathway Decreases the Somatic Expression of Opiate Withdrawal

Escape from the extremely aversive opiate withdrawal symptoms powerfully motivates compulsive drug-seeking and drug-taking behaviors. The corticotropin-releasing factor (CRF) system is hypothesized to mediate the motivational properties of drug dependence. CRF signaling is transmitted by two recepto...

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Main Authors: Papaleo, Francesco, Ghozland, Sandy, Ingallinesi, Manuela, Roberts, Amanda J, Koob, George F, Contarino, Angelo
Format: Artigo
Jezik:English
Izdano: 2008
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2760329/
https://ncbi.nlm.nih.gov/pubmed/18288089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2008.8
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https://ncbi.nlm.nih.gov/pmc/articles/PMC2760329/
https://ncbi.nlm.nih.gov/pubmed/18288089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2008.8

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