Toward Homogeneous Erythropoietin: Chemical Synthesis of the Ala(1)-Gly(28) Glycopeptide Domain by “Alanine” Ligation

The Ala(1)—Gly(28) glycopeptide fragment (28) of EPO was prepared by chemical synthesis as a single glycoform. Key steps in the synthesis include attachment of a complex dodecasaccharide (7) to a seven amino acid peptide via Lansbury aspartylation, native chemical ligation to join peptide 19 with th...

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Bibliografiske detaljer
Main Authors: Kan, Cindy, Trzupek, John D., Wu, Bin, Wan, Qian, Chen, Gong, Tan, Zhongping, Yuan, Yu, Danishefsky, Samuel J.
Format: Artigo
Sprog:English
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2765573/
https://ncbi.nlm.nih.gov/pubmed/19334679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja808707w
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Internet

https://ncbi.nlm.nih.gov/pmc/articles/PMC2765573/
https://ncbi.nlm.nih.gov/pubmed/19334679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja808707w

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