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Cerebral Infarction in IgG Multiple Myeloma with Hyperviscosity

Cerebral infarction is an uncommon complication in multiple myeloma with hyperviscosity. Serum hyperviscosity may cause a variety of clinical manifestations including bleeding from mucosal membranes, congestive heart failure, retinopathy, and various neurologic deficits. These manifestations have be...

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Materialtyp: Artikel
Språk:en
Publicerad: The Korean Academy of Medical Sciences 2005
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782175/
https://ncbi.nlm.nih.gov/pubmed/16100471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3346/jkms.2005.20.4.699
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id pubmed-2782175
record_format dspace
institution US National Library of Medicine
collection PubMed Central
language en
format Article
topic Case Report
spellingShingle Case Report
Cerebral Infarction in IgG Multiple Myeloma with Hyperviscosity
topic_facet Case Report
description Cerebral infarction is an uncommon complication in multiple myeloma with hyperviscosity. Serum hyperviscosity may cause a variety of clinical manifestations including bleeding from mucosal membranes, congestive heart failure, retinopathy, and various neurologic deficits. These manifestations have been attributed to the presence of large quantities of asymmetrical molecules of high molecular weight in the serum. We recently experienced a case of multiple myeloma with acute cerebral infarction, which caused by hyperviscosity, as an initial manifestation in IgG multiple myeloma, and reviewed the relevant literature of myeloma presenting with the stroke. A 68-yr-old woman abruptly developed hypesthesia and monoplegia in the left leg. The stroke confirmed by the brain MRI and MR angiography, which revealed acute infarction at the right anterior cerebral artery territory. On admission, routine blood tests showed a slight decrease in hemoglobin and a marked increase in erythrocyte sedimentation rate. Peripheral blood smear, serum protein electrophoresis, serum visocity, and bone marrow aspiration showed that she had IgG multiple myeloma with hyperviscosity. She was treated by chemotherapy with cyclophosphamide and discharged with the improved clinical condition.
author_sort Park, Man-Seok
title Cerebral Infarction in IgG Multiple Myeloma with Hyperviscosity
title_short Cerebral Infarction in IgG Multiple Myeloma with Hyperviscosity
title_full Cerebral Infarction in IgG Multiple Myeloma with Hyperviscosity
title_fullStr Cerebral Infarction in IgG Multiple Myeloma with Hyperviscosity
title_full_unstemmed Cerebral Infarction in IgG Multiple Myeloma with Hyperviscosity
title_sort cerebral infarction in igg multiple myeloma with hyperviscosity
publisher The Korean Academy of Medical Sciences
publisher_facet The Korean Academy of Medical Sciences
publishDate 2005
url https://ncbi.nlm.nih.gov/pmc/articles/PMC2782175/
https://ncbi.nlm.nih.gov/pubmed/16100471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3346/jkms.2005.20.4.699
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