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G Protein-coupled Receptor Kinase-2 Constitutively Regulates D(2) Dopamine Receptor Expression and Signaling Independently of Receptor Phosphorylation
We investigated the regulatory effects of GRK2 on D(2) dopamine receptor signaling and found that this kinase inhibits both receptor expression and functional signaling in a phosphorylation-independent manner, apparently through different mechanisms. Overexpression of GRK2 was found to suppress rece...
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| Format: | Article |
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| Idioma: | en |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2797181/ https://ncbi.nlm.nih.gov/pubmed/19815545 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.055707 |
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