Lovastatin, an inhibitor of cholesterol synthesis, induces hydroxymethylglutaryl-coenzyme A reductase directly on membranes of expanded smooth endoplasmic reticulum in rat hepatocytes.

Lovastatin is a potent competitive inhibitor of the rate-limiting enzyme of cholesterol synthesis, 3-hydroxy-3-methylglutaryl-coenzyme A reductase (NADPH) [HMG-CoA reductase; (S)-mevalonate:NADP+ oxidoreductase (CoA-acylating), EC 1.1.1.34]. We determined the subcellular distribution of HMG-CoA redu...

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Bibliografski detalji
Glavni autori: Singer, I I, Scott, S, Kazazis, D M, Huff, J W
Format: Članak
Jezik:en
Izdano: 1988
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC281730/
https://ncbi.nlm.nih.gov/pubmed/3293052
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https://ncbi.nlm.nih.gov/pmc/articles/PMC281730/
https://ncbi.nlm.nih.gov/pubmed/3293052

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