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Probing the Antimalarial Mechanism of Artemisinin and OZ277 (Arterolane) with Nonperoxidic Isosteres and Nitroxyl Radicals
Peroxidic antimalarials such as the semisynthetic artemisinins are critically important in the treatment of drug-resistant malaria. Nevertheless, their peroxide bond-dependent mode of action is still not well understood. Using combination experiments with cultured Plasmodium falciparum cells, we inv...
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| Format: | Artigo |
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| Sprog: | en |
| Udgivet: |
American Society for Microbiology (ASM)
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2825978/ https://ncbi.nlm.nih.gov/pubmed/20028825 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01305-09 |
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