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Peptide Chain Termination, VII. The Ribosomal and Release Factor Requirements for Peptide Release
Release factors participate in release of fMet from fMet-tRNA · AUG · ribosome intermediates upon binding to ribosomes. This release requires R factor and occurs in the absence of terminator codon in reactions containing 20 per cent ethanol. Release occurs only when both 30S and 50S ribosomal subuni...
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| Κύριοι συγγραφείς: | , , |
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| Μορφή: | Άρθρο |
| Γλώσσα: | en |
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1970
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC282963/ https://ncbi.nlm.nih.gov/pubmed/4910855 |
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pubmed-282963 |
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pubmed-2829632004-03-13 Peptide Chain Termination, VII. The Ribosomal and Release Factor Requirements for Peptide Release Tompkins, R. K. Scolnick, E. M. Caskey, C. T. Proc Natl Acad Sci U S A Biological Sciences: Biochemistry Release factors participate in release of fMet from fMet-tRNA · AUG · ribosome intermediates upon binding to ribosomes. This release requires R factor and occurs in the absence of terminator codon in reactions containing 20 per cent ethanol. Release occurs only when both 30S and 50S ribosomal subunits are present and when fMet-tRNA is located in the ribosomal P site. Release factor-dependent deacylation of fMet-tRNA is inhibited by sparsomycin, amicetin, lincocin, and chloramphenicol, antibiotics which have little effect on binding of R factor to ribosomes. The possible role of peptidyl transferase in the release reaction is discussed. 1970-03 /pmc/articles/PMC282963/ /pubmed/4910855 Text en |
| institution |
US National Library of Medicine |
| collection |
PubMed Central |
| language |
en |
| format |
Article |
| topic |
Biological Sciences: Biochemistry |
| spellingShingle |
Biological Sciences: Biochemistry Tompkins, R. K. Scolnick, E. M. Caskey, C. T. Peptide Chain Termination, VII. The Ribosomal and Release Factor Requirements for Peptide Release |
| description |
Release factors participate in release of fMet from fMet-tRNA · AUG · ribosome intermediates upon binding to ribosomes. This release requires R factor and occurs in the absence of terminator codon in reactions containing 20 per cent ethanol. Release occurs only when both 30S and 50S ribosomal subunits are present and when fMet-tRNA is located in the ribosomal P site. Release factor-dependent deacylation of fMet-tRNA is inhibited by sparsomycin, amicetin, lincocin, and chloramphenicol, antibiotics which have little effect on binding of R factor to ribosomes. The possible role of peptidyl transferase in the release reaction is discussed. |
| author |
Tompkins, R. K. Scolnick, E. M. Caskey, C. T. |
| author_facet |
Tompkins, R. K. Scolnick, E. M. Caskey, C. T. |
| author_sort |
Tompkins, R. K. |
| title |
Peptide Chain Termination, VII. The Ribosomal and Release Factor Requirements for Peptide Release |
| title_short |
Peptide Chain Termination, VII. The Ribosomal and Release Factor Requirements for Peptide Release |
| title_full |
Peptide Chain Termination, VII. The Ribosomal and Release Factor Requirements for Peptide Release |
| title_fullStr |
Peptide Chain Termination, VII. The Ribosomal and Release Factor Requirements for Peptide Release |
| title_full_unstemmed |
Peptide Chain Termination, VII. The Ribosomal and Release Factor Requirements for Peptide Release |
| title_sort |
peptide chain termination, vii. the ribosomal and release factor requirements for peptide release |
| publishDate |
1970 |
| url |
https://ncbi.nlm.nih.gov/pmc/articles/PMC282963/ https://ncbi.nlm.nih.gov/pubmed/4910855 |
| _version_ |
1759077221671108608 |