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De novo amplification within a "silent" human cholinesterase gene in a family subjected to prolonged exposure to organophosphorous insecticides.

A 100-fold DNA amplification in the CHE gene, coding for serum butyrylcholinesterase (BtChoEase), was found in a farmer expressing the "silent" CHE phenotype. Individuals homozygous for this gene display a defective serum BtChoEase and are particularly vulnerable to poisoning by agricultur...

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Detalles Bibliográficos
Main Authors: Prody, C A, Dreyfus, P, Zamir, R, Zakut, H, Soreq, H
Formato: Artigo
Idioma:en
Publicado: 1989
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC286539/
https://ncbi.nlm.nih.gov/pubmed/2911599
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