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Helical assembly in the MyD88:IRAK4:IRAK2 complex in TLR/IL-1R signaling
MyD88, IRAK4 and IRAK2 are critical signaling mediators of the TLR/IL1-R superfamily. Here we report the crystal structure of the MyD88: IRAK4: IRAK2 death domain (DD) complex, which surprisingly reveals a left-handed helical oligomer that consists of 6 MyD88, 4 IRAK4 and 4 IRAK2 DDs. Assembly of th...
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| Formaat: | Artikel |
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| Taal: | en |
| Gepubliceerd in: |
2010
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2888693/ https://ncbi.nlm.nih.gov/pubmed/20485341 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09121 |
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