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Structure and Mechanism of Human DNA Polymerase η
The variant form of human xeroderma pigmentosum syndrome (XPV) is caused by a deficiency in DNA polymerase η (Pol η) that enables replication through sunlight-induced pyrimidine dimers. We report high-resolution crystal structures of human Pol η at four consecutive steps during DNA synthesis through...
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| Format: | Artigo |
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| Sprog: | en |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2899710/ https://ncbi.nlm.nih.gov/pubmed/20577208 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09196 |
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