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A Hinge Region Cis-proline in Ribonuclease A Acts as a Conformational Gatekeeper for C-terminal Domain Swapping
Domain swapping, the process in which a structural unit is exchanged between monomers to create a dimer containing two versions of the monomeric fold, is believed to be an important mechanism for oligomerization and the formation of amyloid fibrils. Structural studies have implicated proline as an i...
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| Formato: | Artigo |
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| Idioma: | en |
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2010
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2911975/ https://ncbi.nlm.nih.gov/pubmed/20471398 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.05.017 |
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