Lineage-specific T-cell reconstitution following in vivo CD4(+) and CD8(+) lymphocyte depletion in nonhuman primates

Many features of T-cell homeostasis in primates are still unclear, thus limiting our understanding of AIDS pathogenesis, in which T-cell homeostasis is lost. Here, we performed experiments of in vivo CD4(+) or CD8(+) lymphocyte depletion in 2 nonhuman primate species, rhesus macaques (RMs) and sooty...

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Formato: Artigo
Idioma:en
Publicado em: American Society of Hematology 2010
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2918331/
https://ncbi.nlm.nih.gov/pubmed/20484087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-01-263814
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id pubmed-2918331
record_format dspace
institution US National Library of Medicine
collection PubMed Central
language en
format Article
topic Immunobiology
spellingShingle Immunobiology
Lineage-specific T-cell reconstitution following in vivo CD4(+) and CD8(+) lymphocyte depletion in nonhuman primates
topic_facet Immunobiology
description Many features of T-cell homeostasis in primates are still unclear, thus limiting our understanding of AIDS pathogenesis, in which T-cell homeostasis is lost. Here, we performed experiments of in vivo CD4(+) or CD8(+) lymphocyte depletion in 2 nonhuman primate species, rhesus macaques (RMs) and sooty mangabeys (SMs). Whereas RMs develop AIDS after infection with simian immunodeficiency virus (SIV), SIV-infected SMs are typically AIDS-resistant. We found that, in both species, most CD4(+) or CD8(+) T cells in blood and lymph nodes were depleted after treatment with their respective antibodies. These CD4(+) and CD8(+) lymphocyte depletions were followed by a largely lineage-specific CD4(+) and CD8(+) T-cell proliferation, involving mainly memory T cells, which correlated with interleukin-7 plasma levels. Interestingly, SMs showed a faster repopulation of naive CD4(+) T cells than RMs. In addition, in both species CD8(+) T-cell repopulation was faster than that of CD4(+) T cells, with CD8(+) T cells reconstituting a normal pool within 60 days and CD4(+) T cells remaining below baseline levels up to day 180 after depletion. While this study revealed subtle differences in CD4(+) T-cell repopulation in an AIDS-sensitive versus an AIDS-resistant species, such differences may have particular relevance in the presence of active SIV repli cation, where CD4(+) T-cell destruction is chronic.
author_sort Engram, Jessica C.
title Lineage-specific T-cell reconstitution following in vivo CD4(+) and CD8(+) lymphocyte depletion in nonhuman primates
title_short Lineage-specific T-cell reconstitution following in vivo CD4(+) and CD8(+) lymphocyte depletion in nonhuman primates
title_full Lineage-specific T-cell reconstitution following in vivo CD4(+) and CD8(+) lymphocyte depletion in nonhuman primates
title_fullStr Lineage-specific T-cell reconstitution following in vivo CD4(+) and CD8(+) lymphocyte depletion in nonhuman primates
title_full_unstemmed Lineage-specific T-cell reconstitution following in vivo CD4(+) and CD8(+) lymphocyte depletion in nonhuman primates
title_sort lineage-specific t-cell reconstitution following in vivo cd4(+) and cd8(+) lymphocyte depletion in nonhuman primates
publisher American Society of Hematology
publisher_facet American Society of Hematology
publishDate 2010
url https://ncbi.nlm.nih.gov/pmc/articles/PMC2918331/
https://ncbi.nlm.nih.gov/pubmed/20484087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-01-263814
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