Antineoplastic bryostatins are multipotential stimulators of human hematopoietic progenitor cells.

The bryostatins are macrocyclic lactones, extracted from the marine bryozoan Bugula neritina, and have been reported to be potent antineoplastic agents. Results described here demonstrate that the bryostatins may also be useful as stimulators of normal human hematopoietic cells since they can (i) di...

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Autors principals: May, W S, Sharkis, S J, Esa, A H, Gebbia, V, Kraft, A S, Pettit, G R, Sensenbrenner, L L
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Idioma:en
Publicat: 1987
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC299568/
https://ncbi.nlm.nih.gov/pubmed/3317410
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spelling pubmed-2995682004-02-02 Antineoplastic bryostatins are multipotential stimulators of human hematopoietic progenitor cells. May, W S Sharkis, S J Esa, A H Gebbia, V Kraft, A S Pettit, G R Sensenbrenner, L L Proc Natl Acad Sci U S A Research Article The bryostatins are macrocyclic lactones, extracted from the marine bryozoan Bugula neritina, and have been reported to be potent antineoplastic agents. Results described here demonstrate that the bryostatins may also be useful as stimulators of normal human hematopoietic cells since they can (i) directly stimulate bone marrow progenitor cells to form colonies in vitro and (ii) functionally activate neutrophils. Structure-activity studies with bryostatin congeners indicate that these stimulatory properties may be dependent on the chain length and the unsaturated nature of the acylated group at carbons 20 and 7 of the bryostatin molecule. These stimulatory properties demonstrate that the naturally occurring bryostatins can mimic many of the biological effects of multipotential granulocyte-macrophage colony-stimulating factor. Thus, the coupling of antineoplastic activity with stimulatory growth properties for normal hematopoietic cells makes this agent an excellent probe to dissect the mechanism(s) of normal hematopoiesis. In addition, bryostatin may represent a clinically attractive agent useful for treating bone marrow failure states. 1987-12 /pmc/articles/PMC299568/ /pubmed/3317410 Text en
institution US National Library of Medicine
collection PubMed Central
language en
format Article
topic Research Article
spellingShingle Research Article
May, W S
Sharkis, S J
Esa, A H
Gebbia, V
Kraft, A S
Pettit, G R
Sensenbrenner, L L
Antineoplastic bryostatins are multipotential stimulators of human hematopoietic progenitor cells.
description The bryostatins are macrocyclic lactones, extracted from the marine bryozoan Bugula neritina, and have been reported to be potent antineoplastic agents. Results described here demonstrate that the bryostatins may also be useful as stimulators of normal human hematopoietic cells since they can (i) directly stimulate bone marrow progenitor cells to form colonies in vitro and (ii) functionally activate neutrophils. Structure-activity studies with bryostatin congeners indicate that these stimulatory properties may be dependent on the chain length and the unsaturated nature of the acylated group at carbons 20 and 7 of the bryostatin molecule. These stimulatory properties demonstrate that the naturally occurring bryostatins can mimic many of the biological effects of multipotential granulocyte-macrophage colony-stimulating factor. Thus, the coupling of antineoplastic activity with stimulatory growth properties for normal hematopoietic cells makes this agent an excellent probe to dissect the mechanism(s) of normal hematopoiesis. In addition, bryostatin may represent a clinically attractive agent useful for treating bone marrow failure states.
author May, W S
Sharkis, S J
Esa, A H
Gebbia, V
Kraft, A S
Pettit, G R
Sensenbrenner, L L
author_facet May, W S
Sharkis, S J
Esa, A H
Gebbia, V
Kraft, A S
Pettit, G R
Sensenbrenner, L L
author_sort May, W S
title Antineoplastic bryostatins are multipotential stimulators of human hematopoietic progenitor cells.
title_short Antineoplastic bryostatins are multipotential stimulators of human hematopoietic progenitor cells.
title_full Antineoplastic bryostatins are multipotential stimulators of human hematopoietic progenitor cells.
title_fullStr Antineoplastic bryostatins are multipotential stimulators of human hematopoietic progenitor cells.
title_full_unstemmed Antineoplastic bryostatins are multipotential stimulators of human hematopoietic progenitor cells.
title_sort antineoplastic bryostatins are multipotential stimulators of human hematopoietic progenitor cells.
publishDate 1987
url https://ncbi.nlm.nih.gov/pmc/articles/PMC299568/
https://ncbi.nlm.nih.gov/pubmed/3317410
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