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Cleavage of full-length beta APP mRNA by hammerhead ribozymes.
The sequences surrounding the first 5'GUC3' in the mRNA encoding the Alzheimer amyloid peptide precursor (beta APP) were used to construct a pair of transacting hammerhead ribozymes. Each ribozyme contained the conserved core bases of the hammerhead motif found in the positive strand of sa...
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| Main Author: | |
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| Format: | Article |
| Language: | en |
| Published: |
1993
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| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC310017/ https://ncbi.nlm.nih.gov/pubmed/8371986 |
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