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Aminoacyl RNA domain of turnip yellow mosaic virus Val-RNA interacting with elongation factor Tu
Turnip yellow mosaic virus (TYMV) Val-RNA forms a complex with the peptide elongation factor Tu (EF-Tu) in the presence of GTP: the Val-RNA is protected by EF-Tu·GTP from non-enzymatic deacylation and nuclease digestion. The determination of the length of the shortest TYMV Val-RNA fragment that bind...
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| Auteurs principaux: | , , , , |
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| Format: | Article |
| Langue: | en |
| Publié: |
1984
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| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC320175/ https://ncbi.nlm.nih.gov/pubmed/16617475 |
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| Résumé: | Turnip yellow mosaic virus (TYMV) Val-RNA forms a complex with the peptide elongation factor Tu (EF-Tu) in the presence of GTP: the Val-RNA is protected by EF-Tu·GTP from non-enzymatic deacylation and nuclease digestion. The determination of the length of the shortest TYMV Val-RNA fragment that binds EF-Tu·GTP leads us to conclude that the valylated aminoacyl RNA domain equivalent in tRNAs to the continuous helix formed by the acceptor stem and the T arm is sufficient for complex formation. Since the aminoacyl RNA domain is also sufficient for adenylation by the ATP(CTP):tRNA nucleotidyltransferase, an analogy can be drawn between these two tRNA-specific proteins. |
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