Design of potent, orally effective, nonpeptidal antagonists of the peptide hormone cholecystokinin.

We describe the design and synthesis of nonpeptidal antagonists of the peptide hormone cholecystokinin. Several of these compounds have high specificity and nanomolar binding affinity and are active after oral administration. To our knowledge, the design of such agents has not previously been accomp...

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Bibliografiske detaljer
Main Authors: Evans, B E, Bock, M G, Rittle, K E, DiPardo, R M, Whitter, W L, Veber, D F, Anderson, P S, Freidinger, R M
Format: Artigo
Sprog:en
Udgivet: 1986
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC323855/
https://ncbi.nlm.nih.gov/pubmed/3014519
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Internet

https://ncbi.nlm.nih.gov/pmc/articles/PMC323855/
https://ncbi.nlm.nih.gov/pubmed/3014519

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