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Distinct TLR adjuvants differentially stimulate systemic and local innate immune responses in nonhuman primates
TLR ligands (TLR-Ls) represent novel vaccine adjuvants, but their immunologic effects in humans remain poorly defined in vivo. In the present study, we analyzed the innate responses stimulated by different TLR-Ls in rhesus macaques. MPL (TLR4-L), R-848 (TLR7/8-L), or cytosine-phosphate-guanine oligo...
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| Format: | Artikel |
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| Sprache: | en |
| Veröffentlicht: |
American Society of Hematology
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3311246/ https://ncbi.nlm.nih.gov/pubmed/22246032 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-10-388579 |
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