Dynamic properties of the Ras switch I region and its importance for binding to effectors

We have investigated the dynamic properties of the switch I region of the GTP-binding protein Ras by using mutants of Thr-35, an invariant residue necessary for the switch function. Here we show that these mutants, previously used as partial loss-of-function mutations in cell-based assays, have a re...

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Bibliografiska uppgifter
Huvudupphovsmän: Spoerner, Michael, Herrmann, Christian, Vetter, Ingrid R., Kalbitzer, Hans Robert, Wittinghofer, Alfred
Materialtyp: Artikel
Språk:en
Publicerad: The National Academy of Sciences 2001
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC33143/
https://ncbi.nlm.nih.gov/pubmed/11320243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.081441398
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Internet

https://ncbi.nlm.nih.gov/pmc/articles/PMC33143/
https://ncbi.nlm.nih.gov/pubmed/11320243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.081441398

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