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The hypersensitive sites of the murine β-globin locus control region act independently to affect nuclear localization and transcriptional elongation
The β-globin locus control region (LCR) is necessary for high-level β-globin gene transcription and differentiation-dependent relocation of the β-globin locus from the nuclear periphery to the central nucleoplasm and to foci of hyperphosphorylated Pol II “transcription factories” (TFys). To determin...
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| Format: | Article |
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| Idioma: | en |
| Publicat: |
American Society of Hematology
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3335386/ https://ncbi.nlm.nih.gov/pubmed/22378846 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-09-380485 |
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