Opiate-Induced Molecular and Cellular Plasticity of Ventral Tegmental Area and Locus Coeruleus Catecholamine Neurons

The study of neuronal adaptations induced by opiate drugs is particularly relevant today given their widespread prescription and nonprescription use. Although much is known about the acute actions of such drugs on the nervous system, a great deal of work remains to fully understand their chronic eff...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Formato: Artigo
Idioma:en
Publicado em: Cold Spring Harbor Laboratory Press 2012
Assuntos:
Perspectives
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3385942/
https://ncbi.nlm.nih.gov/pubmed/22762025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a012070
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
id pubmed-3385942
record_format dspace
institution US National Library of Medicine
collection PubMed Central
language en
format Article
topic Perspectives
spellingShingle Perspectives
Opiate-Induced Molecular and Cellular Plasticity of Ventral Tegmental Area and Locus Coeruleus Catecholamine Neurons
topic_facet Perspectives
description The study of neuronal adaptations induced by opiate drugs is particularly relevant today given their widespread prescription and nonprescription use. Although much is known about the acute actions of such drugs on the nervous system, a great deal of work remains to fully understand their chronic effects. Here, we focus on longer-lasting adaptations that occur in two catecholaminergic brain regions that mediate distinct behavioral actions of opiates: ventral tegmental area (VTA) dopaminergic neurons, important for drug reward, and locus coeruleus (LC) noradrenergic neurons, important for physical dependence and withdrawal. We focus on changes in cellular, synaptic, and structural plasticity in these brain regions that contribute to opiate dependence and addiction. Understanding the molecular determinants of this opiate–induced plasticity will be critical for the development of better treatments for opiate addiction and perhaps safer opiate drugs for medicinal use.
author_sort Mazei-Robison, Michelle S.
title Opiate-Induced Molecular and Cellular Plasticity of Ventral Tegmental Area and Locus Coeruleus Catecholamine Neurons
title_short Opiate-Induced Molecular and Cellular Plasticity of Ventral Tegmental Area and Locus Coeruleus Catecholamine Neurons
title_full Opiate-Induced Molecular and Cellular Plasticity of Ventral Tegmental Area and Locus Coeruleus Catecholamine Neurons
title_fullStr Opiate-Induced Molecular and Cellular Plasticity of Ventral Tegmental Area and Locus Coeruleus Catecholamine Neurons
title_full_unstemmed Opiate-Induced Molecular and Cellular Plasticity of Ventral Tegmental Area and Locus Coeruleus Catecholamine Neurons
title_sort opiate-induced molecular and cellular plasticity of ventral tegmental area and locus coeruleus catecholamine neurons
publisher Cold Spring Harbor Laboratory Press
publisher_facet Cold Spring Harbor Laboratory Press
publishDate 2012
url https://ncbi.nlm.nih.gov/pmc/articles/PMC3385942/
https://ncbi.nlm.nih.gov/pubmed/22762025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a012070
_version_ 1872504955173076993

Registos relacionados