Rearrangement of immunoglobulin gamma 1-chain gene and mechanism for heavy-chain class switch.

Cloning and nucleotide sequence determination suggest that the rearranged gamma 1-chain gene in a gamma 1-chain-producing myeloma a-pears to be formed by the recombination between the 5' flanking regions of the gamma 1- and mu-chain genes of undifferentiated cells. The recombination site is dis...

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Päätekijät: Kataoka, T, Kawakami, T, Takahashi, N, Honjo, T
Aineistotyyppi: Artikkeli
Kieli:en
Julkaistu: 1980
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC348393/
https://ncbi.nlm.nih.gov/pubmed/6767246
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spelling pubmed-3483932004-03-13 Rearrangement of immunoglobulin gamma 1-chain gene and mechanism for heavy-chain class switch. Kataoka, T Kawakami, T Takahashi, N Honjo, T Proc Natl Acad Sci U S A Research Article Cloning and nucleotide sequence determination suggest that the rearranged gamma 1-chain gene in a gamma 1-chain-producing myeloma a-pears to be formed by the recombination between the 5' flanking regions of the gamma 1- and mu-chain genes of undifferentiated cells. The recombination site is distinct from the putative J region and is a novel region that we call the S region. We have extended our previous model that explains the heavy-chain class switching by two or more successive recombination events. 1980-02 /pmc/articles/PMC348393/ /pubmed/6767246 Text en
institution US National Library of Medicine
collection PubMed Central
language en
format Article
topic Research Article
spellingShingle Research Article
Kataoka, T
Kawakami, T
Takahashi, N
Honjo, T
Rearrangement of immunoglobulin gamma 1-chain gene and mechanism for heavy-chain class switch.
description Cloning and nucleotide sequence determination suggest that the rearranged gamma 1-chain gene in a gamma 1-chain-producing myeloma a-pears to be formed by the recombination between the 5' flanking regions of the gamma 1- and mu-chain genes of undifferentiated cells. The recombination site is distinct from the putative J region and is a novel region that we call the S region. We have extended our previous model that explains the heavy-chain class switching by two or more successive recombination events.
author Kataoka, T
Kawakami, T
Takahashi, N
Honjo, T
author_facet Kataoka, T
Kawakami, T
Takahashi, N
Honjo, T
author_sort Kataoka, T
title Rearrangement of immunoglobulin gamma 1-chain gene and mechanism for heavy-chain class switch.
title_short Rearrangement of immunoglobulin gamma 1-chain gene and mechanism for heavy-chain class switch.
title_full Rearrangement of immunoglobulin gamma 1-chain gene and mechanism for heavy-chain class switch.
title_fullStr Rearrangement of immunoglobulin gamma 1-chain gene and mechanism for heavy-chain class switch.
title_full_unstemmed Rearrangement of immunoglobulin gamma 1-chain gene and mechanism for heavy-chain class switch.
title_sort rearrangement of immunoglobulin gamma 1-chain gene and mechanism for heavy-chain class switch.
publishDate 1980
url https://ncbi.nlm.nih.gov/pmc/articles/PMC348393/
https://ncbi.nlm.nih.gov/pubmed/6767246
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